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Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes.
Alkanani, Aimon K; Hara, Naoko; Gottlieb, Peter A; Ir, Diana; Robertson, Charles E; Wagner, Brandie D; Frank, Daniel N; Zipris, Danny.
Afiliação
  • Alkanani AK; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO.
  • Hara N; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO.
  • Gottlieb PA; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO.
  • Ir D; Division of Infectious Diseases, School of Medicine, University of Colorado Denver, Aurora, CO.
  • Robertson CE; Division of Infectious Diseases, School of Medicine, University of Colorado Denver, Aurora, CO University of Colorado Denver Microbiome Research Consortium, School of Medicine, University of Colorado Denver, Aurora, CO.
  • Wagner BD; University of Colorado Denver Microbiome Research Consortium, School of Medicine, University of Colorado Denver, Aurora, CO Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Aurora, CO.
  • Frank DN; Division of Infectious Diseases, School of Medicine, University of Colorado Denver, Aurora, CO University of Colorado Denver Microbiome Research Consortium, School of Medicine, University of Colorado Denver, Aurora, CO.
  • Zipris D; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO danny.zipris@ucdenver.edu.
Diabetes ; 64(10): 3510-20, 2015 Oct.
Article em En | MEDLINE | ID: mdl-26068542
We tested the hypothesis that alterations in the intestinal microbiota are linked with the progression of type 1 diabetes (T1D). Herein, we present results from a study performed in subjects with islet autoimmunity living in the U.S. High-throughput sequencing of bacterial 16S rRNA genes and adjustment for sex, age, autoantibody presence, and HLA indicated that the gut microbiomes of seropositive subjects differed from those of autoantibody-free first-degree relatives (FDRs) in the abundance of four taxa. Furthermore, subjects with autoantibodies, seronegative FDRs, and new-onset patients had different levels of the Firmicutes genera Lactobacillus and Staphylococcus compared with healthy control subjects with no family history of autoimmunity. Further analysis revealed trends toward increased and reduced abundances of the Bacteroidetes genera Bacteroides and Prevotella, respectively, in seropositive subjects with multiple versus one autoantibody. Canonical discriminant analysis suggested that the gut microbiomes of autoantibody-positive individuals and seronegative FDRs clustered together but separate from those of new-onset patients and unrelated healthy control subjects. Finally, no differences in biodiversity were evident in seropositive versus seronegative FDRs. These observations suggest that altered intestinal microbiota may be associated with disease susceptibility.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Ilhotas Pancreáticas / Diabetes Mellitus Tipo 1 / Microbioma Gastrointestinal Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Diabetes Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Ilhotas Pancreáticas / Diabetes Mellitus Tipo 1 / Microbioma Gastrointestinal Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Diabetes Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos