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Vitamin B complex attenuated heat hyperalgesia following infraorbital nerve constriction in rats and reduced capsaicin in vivo and in vitro effects.
Kopruszinski, Caroline M; Reis, Renata C; Bressan, Elisangela; Reeh, Peter W; Chichorro, Juliana G.
Afiliação
  • Kopruszinski CM; Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil.
  • Reis RC; Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil.
  • Bressan E; Institute of Physiology and Pathophysiology, University of Erlangen-Nuremberg, Erlangen D-91054, Germany.
  • Reeh PW; Institute of Physiology and Pathophysiology, University of Erlangen-Nuremberg, Erlangen D-91054, Germany.
  • Chichorro JG; Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil. Electronic address: juliana.chichorro@ufpr.br.
Eur J Pharmacol ; 762: 326-32, 2015 Sep 05.
Article em En | MEDLINE | ID: mdl-26048309
Vitamins of the B complex attenuate some neuropathic pain sensory aspects in various animal models and in patients, but the mechanisms underlying their effects remain to be elucidated. Herein it was investigated if the treatment with a vitamin B complex (VBC) reduces heat hyperalgesia in rats submitted to infraorbital nerve constriction and the possibility that TRPV1 receptors represent a target for B vitamins. In the present study, the VBC refers to a combination of vitamins B1, B6 and B12 at low- (18, 18 and 1.8mg/kg, respectively) or high- (180, 180 and 18mg/kg, respectively) doses. Acute treatment of rats with either the low- or the high-doses combination reduced heat hyperalgesia after nerve injury, but the high-doses combination resulted in a long-lasting effect. Repeated treatment with the low-dose combination reduced heat hyperalgesia on day four after nerve injury and showed a synergist effect with a single injection of carbamazepine (3 or 10mg/kg), which per se failed to modify the heat threshold. In naïve rats, acute treatment with the high-dose of VBC or B1 and B12 vitamins independently reduced heat hyperalgesia evoked by capsaicin (3µg into the upper lip). Moreover, the VBC, as well as, each one of the B vitamins independently reduced the capsaicin-induced calcium responses in HEK 293 cells transiently transfected with the human TRPV1 channels. Altogether, these results indicate that B vitamins can be useful to control heat hyperalgesia associated with trigeminal neuropathic pain and that modulation of TRPV1 receptors may contribute to their anti-hyperalgesic effects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Órbita / Complexo Vitamínico B / Capsaicina / Hiperalgesia Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Órbita / Complexo Vitamínico B / Capsaicina / Hiperalgesia Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda