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Chronic High Fat Diet Consumption Impairs Metabolic Health of Male Mice.
Morselli, Eugenia; Criollo, Alfredo; Rodriguez-Navas, Carlos; Clegg, Deborah J.
Afiliação
  • Morselli E; Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, 8331150, Santiago, Chile.
  • Criollo A; Laboratory of Cellular and Molecular Biology, Research Institute of Dental Science and Advanced Center for Chronic Diseases (ACCDiS), Faculty of Dentistry, University of Chile, 8380492 Santiago, Chile.
  • Rodriguez-Navas C; Department of Molecular Genetics, University of Texas Southwestern Medical Center, 75390-8857, Dallas, Texas, USA.
  • Clegg DJ; Cedars-Sinai Diabetes and Obesity Research Institute, Department of Biomedical Research, 90048, Los Angeles, California, USA.
Inflamm Cell Signal ; 1(6): e561, 2014.
Article em En | MEDLINE | ID: mdl-26046098
We show that chronic high fat diet (HFD) feeding affects the hypothalamus of male but not female mice. In our study we demonstrate that palmitic acid and sphingolipids accumulate in the central nervous system of HFD-fed males. Additionally, we show that HFD-feeding reduces proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) thus reducing estrogen receptor α (ERα) and driving hypothalamic inflammation in male but not female mice. Hypothalamic inflammation correlates with markers of metabolic dysregulation as indicated by dysregulation in glucose intolerance and myocardial function. Lastly, we demonstrate that there are blockages in mitophagy and lipophagy in hypothalamic tissues in males. Our data suggest there is a sexually dimorphic response to chronic HDF exposure, females; despite gaining the same amount of body weight following HFD-feeding, appear to be protected from the adverse metabolic effects of the HFD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Inflamm Cell Signal Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Inflamm Cell Signal Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos