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Perinatal exposure to androgen excess and the effects on the rat uterine estradiol responsiveness.
Guerra, Marina T; Sanabria, Marciana; Petrusz, Peter; De Grava Kempinas, Wilma.
Afiliação
  • Guerra MT; Department of Morphology, Institute of Biosciences, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil. marinatguerra@gmail.com.
  • Sanabria M; Department of Morphology, Institute of Biosciences, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Petrusz P; Department of Cell and Developmental Biology and Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, North Carolina, USA.
  • De Grava Kempinas W; Department of Morphology, Institute of Biosciences, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
Environ Toxicol ; 31(11): 1460-1468, 2016 Nov.
Article em En | MEDLINE | ID: mdl-26031391
Androgen exposure during sexual development induces alterations in steroidal target tissues. The objective of this study was to evaluate the uterine responsiveness to estradiol after perinatal androgenization. Pregnant Wistar rats were exposed to corn oil or testosterone propionate at 0.05, 0.1, or 0.2 mg/kg from gestational day 12 until postnatal day 21. Female offspring was challenged with estradiol (E2 ) after weaning (0.4 mg/kg) and at adulthood (10 or 100 µg/day), when the pituitary response was also evaluated. At adulthood, control and 0.05 mg/kg groups presented a uterine weight increment when exposed to 100 µg/day of E2 , 0.1 mg/kg group only responded to 10 µg/day of E2 , and the 0.2 mg/kg group showed increased uterine weight at both doses. The pituitary weight was similarly increased after estradiol stimulation in all experimental groups. In conclusion, testosterone propionate exposure induced an abnormal stimulation of uterine tissue growth by estrogen stimulus without affecting pituitary response. More studies are needed to clarify whether these alterations are capable of impairing the reproductive capacity of the female tract. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1460-1468, 2016.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Útero / Propionato de Testosterona / Estradiol Limite: Animals / Pregnancy Idioma: En Revista: Environ Toxicol Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Útero / Propionato de Testosterona / Estradiol Limite: Animals / Pregnancy Idioma: En Revista: Environ Toxicol Assunto da revista: SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos