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CTLA4 enhances the osteogenic differentiation of allogeneic human mesenchymal stem cells in a model of immune activation.
Dai, F; Zhang, F; Sun, D; Zhang, Z H; Dong, S W; Xu, J Z.
Afiliação
  • Dai F; Department of Orthopedics, National and Regional United Engineering Laboratory of Tissue Engineering, Third Military Medical University, Chongqing, China.
  • Zhang F; Department of Orthopedics, National and Regional United Engineering Laboratory of Tissue Engineering, Third Military Medical University, Chongqing, China.
  • Sun D; Department of Orthopedics, National and Regional United Engineering Laboratory of Tissue Engineering, Third Military Medical University, Chongqing, China.
  • Zhang ZH; Department of Orthopedics, National and Regional United Engineering Laboratory of Tissue Engineering, Third Military Medical University, Chongqing, China.
  • Dong SW; School of Biomedical Engineering, Department of Biomedical Materials Science, Third Military Medical University, Chongqing, China.
  • Xu JZ; Department of Orthopedics, National and Regional United Engineering Laboratory of Tissue Engineering, Third Military Medical University, Chongqing, China.
Braz J Med Biol Res ; 48(7): 629-36, 2015 Jul.
Article em En | MEDLINE | ID: mdl-26017342
Allogeneic mesenchymal stem cells (allo-MSCs) have recently garnered increasing interest for their broad clinical therapy applications. Despite this, many studies have shown that allo-MSCs are associated with a high rate of graft rejection unless immunosuppressive therapy is administered to control allo-immune responses. Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a co-inhibitory molecule expressed on T cells that mediates the inhibition of T-cell function. Here, we investigated the osteogenic differentiation potency of allo-MSCs in an activated immune system that mimics the in vivo allo-MSC grafting microenvironment and explored the immunomodulatory role of the helper T cell receptor CTLA4 in this process. We found that MSC osteogenic differentiation was inhibited in the presence of the activated immune response and that overexpression of CTLA4 in allo-MSCs suppressed the immune response and promoted osteogenic differentiation. Our results support the application of CTLA4-overexpressing allo-MSCs in bone tissue engineering.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese / Linfócitos T / Terapia de Imunossupressão / Transplante de Células-Tronco Mesenquimais / Células-Tronco Mesenquimais / Antígeno CTLA-4 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese / Linfócitos T / Terapia de Imunossupressão / Transplante de Células-Tronco Mesenquimais / Células-Tronco Mesenquimais / Antígeno CTLA-4 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil