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Unraveling Brazilian Indian population prostate good health: clinical, anthropometric and genetic features.
Lima Junior, Mario M de; Reis, Leonardo O; Ferreira, Ubirajara; Cardoso, Ulieme Oliveira; Barbieri, Raquel Bueno; Mendonça, Gustavo B de; Ward, Laura S.
Afiliação
  • Lima Junior MM; Departments of Genetics and Urology, School of Medical Sciences, University of Campinas, UNICAMP, Campinas, São Paulo, Brazil.
  • Reis LO; Departments of Genetics and Urology, School of Medical Sciences, University of Campinas, UNICAMP, Campinas, São Paulo, Brazil.
  • Ferreira U; Departments of Genetics and Urology, School of Medical Sciences, University of Campinas, UNICAMP, Campinas, São Paulo, Brazil.
  • Cardoso UO; Departments of Genetics and Urology, School of Medical Sciences, University of Campinas, UNICAMP, Campinas, São Paulo, Brazil.
  • Barbieri RB; Departments of Genetics and Urology, School of Medical Sciences, University of Campinas, UNICAMP, Campinas, São Paulo, Brazil.
  • Mendonça GB; Departments of Genetics and Urology, School of Medical Sciences, University of Campinas, UNICAMP, Campinas, São Paulo, Brazil.
  • Ward LS; Departments of Genetics and Urology, School of Medical Sciences, University of Campinas, UNICAMP, Campinas, São Paulo, Brazil.
Int Braz J Urol ; 41(2): 344-52, 2015.
Article em En | MEDLINE | ID: mdl-26005978
PURPOSE: To compare dietary, lifestyle, clinical, anthropometric, genetic and prostatic features of Brazilian Indians and non-Indians (Amazon). METHODS: 315 men, 228 Indians and 89 non-Indians, ≥ 40 years old were submitted to digital rectal examination, serum prostate specific antigen (PSA), testosterone, TP53 and GSTP1 genotyping, anthropometric, lifestyle, dietary, personal and familial medical history. Prostatic symptoms were evaluated with the International Prostate Symptom Score (IPSS). RESULTS: Macuxis and Yanomamis represented 43.6% and 14.5% of Indians respectively who spontaneously referred no prostate symptoms. Mean IPSS was 7, range 3-19, with only 15% of moderate symptoms (score 8-19); Mean age was 54.7 years, waist circumference 86.6 cm, BMI 23.9 kg/m(2). Yanomamis presented both lower BMI (21.4 versus 24.8 and 23.3, p=0,001) and prostate volume than Macuxis and "other ethnic groups" (15 versus 20, p=0.001). Testosterone (414 versus 502 and 512, p=0.207) and PSA (0.48 versus 0.6 and 0.41, p=0.349) were similar with progressive PSA increase with aging. Val/Val correlated with lower PSA (p=0.0361). Indians compared to control population presented: - TP53 super representation of Arg/Arg haplotype, 74.5% versus 42.5%, p<0.0001. -GSTP1 Ile/Ile 35.3% versus 60.9%; Ile/Val 45.9% versus 28.7%; Val/Val 18.8% versus 10.3%; p=0.0003. CONCLUSIONS: Observed specific dietary, lifestyle, anthropometric and genetic profile for TP53 and GSTP1 may contribute to Brazilian Indian population prostate good health.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Doenças Prostáticas / Indígenas Sul-Americanos / Antropometria Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Doenças Prostáticas / Indígenas Sul-Americanos / Antropometria Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil