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Prostate-Specific Antigen fluctuation: what does it mean in diagnosis of prostate cancer?
Kim, Jun Seok; Ryu, Je-Guk; Kim, Jin Woong; Hwang, Eu Chang; Jung, Seung Il; Kang, Taek Won; Kwon, Dongdeuk; Park, Kwangsung.
Afiliação
  • Kim JS; Department of Urology, Kwangju Christian Hospital, Gwangju.
  • Ryu JG; Departments of Urology and Radiology, Research Institute of Medical Sciences, Chonnam National University Hospital, Gwangju, Korea.
  • Kim JW; Departments of Urology and Radiology, Research Institute of Medical Sciences, Chonnam National University Hospital, Gwangju, Korea.
  • Hwang EC; Departments of Urology and Radiology, Research Institute of Medical Sciences, Chonnam National University Hospital, Gwangju, Korea.
  • Jung SI; Departments of Urology and Radiology, Research Institute of Medical Sciences, Chonnam National University Hospital, Gwangju, Korea.
  • Kang TW; Departments of Urology and Radiology, Research Institute of Medical Sciences, Chonnam National University Hospital, Gwangju, Korea.
  • Kwon D; Departments of Urology and Radiology, Research Institute of Medical Sciences, Chonnam National University Hospital, Gwangju, Korea.
  • Park K; Departments of Urology and Radiology, Research Institute of Medical Sciences, Chonnam National University Hospital, Gwangju, Korea.
Int Braz J Urol ; 41(2): 258-64, 2015.
Article em En | MEDLINE | ID: mdl-26005966
OBJECTIVE: To investigate whether prostate-specific antigen (PSA) fluctuation correlates with a prostate cancer and to assess whether PSA fluctuation could be used for diagnosis of prostate cancer. MATERIALS AND METHODS: Our study included 229 patients who were performed a prostate biopsy (non-cancer group, 177; prostate cancer group, 52). Enrolled patients were provided twice PSA tests within 6 months. PSA fluctuation (%/month) was defined as a change rate of PSA per a month. Independent t test was used to compare between two groups. Receiver operator characteristic curve was used to assess the availability as a differential diagnostic tool and the correlation. Simple linear regression was performed to analyze a correlation between PSA fluctuation and other factors such as age, PSA, PSA density, and prostate volume. RESULTS: There were significant differences in PSA, PSA density, percentage of free PSA, and PSA fluctuation between two groups. PSA fluctuation was significantly greater in non-cancer group than prostate cancer group (19.95 ± 23.34%/month vs 9.63 ± 8.57%/ month, P=0.004). The most optimal cut-off value of PSA fluctuation was defined as 8.48%/month (sensitivity, 61.6%; specificity, 59.6%; AUC, 0.633; P=0.004). In a simple linear regression model, only PSA level was significantly correlated with PSA fluctuation. CONCLUSION: Patients with wide PSA fluctuations, although baseline PSA levels are high, might have a low risk of diagnosis with prostate cancer. Thus, serial PSA measurements could be an option in patients with an elevated PSA level.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Neoplasias da Próstata / Antígeno Prostático Específico Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Neoplasias da Próstata / Antígeno Prostático Específico Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de publicação: Brasil