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Surfactant protein a expression in chronic rhinosinusitis and atrophic rhinitis.
El-Anwar, Mohammad Waheed; Hamed, Atef A; Mohamed, Abd ElRaof Said; Nofal, Ahmad Abdel-Fattah; Mohamed, Maha A; Abdel-Aziz, Hesham R.
Afiliação
  • El-Anwar MW; Department of Otorhinolaryngology, Head and Neck Surgery, Zagazig University, Zagazig, Egypt.
  • Hamed AA; Department of Otorhinolaryngology, Head and Neck Surgery, Zagazig University, Zagazig, Egypt.
  • Mohamed AE; Department of Otorhinolaryngology, Head and Neck Surgery, Zagazig University, Zagazig, Egypt.
  • Nofal AA; Department of Otorhinolaryngology, Head and Neck Surgery, Zagazig University, Zagazig, Egypt.
  • Mohamed MA; Department of Clinical Pathology, Zagazig University, Zagazig, Egypt.
  • Abdel-Aziz HR; Department of Pathology, Zagazig University, Zagazig, Egypt.
Int Arch Otorhinolaryngol ; 19(2): 130-4, 2015 Apr.
Article em En | MEDLINE | ID: mdl-25992168
Introduction Surfactant protein A (SP-A) exhibits antimicrobial properties and interacts with a variety of respiratory tract pathogens. Objective The objective of this study was to detect the presence of SP-A and measure its alterations in chronic rhinosinusitis (CRS) and primary atrophic rhinitis (PAR) versus healthy controls. Methods Inferior turbinate and sinus mucosal biopsies were taken from 30 patients with CRS, 30 patients with PAR, and 20 healthy controls. Immunohistochemical staining for SP-A and polymerase chain reaction (PCR) amplification of SP-A messenger RNA were performed on nasal tissue samples. Results Immunostaining localized SP-A to the mucosa and submucosal glands in CRS specimens but failed to localize it in PAR specimens. Quantitative PCR showed a high, statistically significant increase in the SP-A levels of patients with CRS when compared with controls (p < 0.0001) and also demonstrated a significant reduction of SP-A in patients with PAR compared with controls (p < 0.005). Conclusion SP-A is significantly increased in CRS and decreased significantly in PAR and appears to be expressed by respiratory epithelial cells and submucosal glandular elements of the sinonasal mucosa. The potential therapeutic applications of surfactant in the enhancement of mucociliary clearance need to be studied.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int Arch Otorhinolaryngol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Egito País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int Arch Otorhinolaryngol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Egito País de publicação: Brasil