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Esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma: differentiation in diagnosis and treatment.
Su, Shirley Y; Bell, Diana; Hanna, Ehab Y.
Afiliação
  • Su SY; Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
  • Bell D; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
  • Hanna EY; Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
Int Arch Otorhinolaryngol ; 18(Suppl 2): S149-56, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25992139
Introduction Malignant sinonasal tumors comprise less than 1% of all neoplasms. A wide variety of tumors occurring primarily in this site can present with an undifferentiated or poorly differentiated morphology. Among them are esthesioneuroblastomas, sinonasal undifferentiated carcinomas, and neuroendocrine carcinomas. Objectives We will discuss diagnostic strategies, recent advances in immunohistochemistry and molecular diagnosis, and treatment strategies. Data Synthesis These lesions are diagnostically challenging, and up to 30% of sinonasal malignancies referred to the University of Texas MD Anderson Cancer Center are given a different diagnosis on review of pathology. Correct classification is vital, as these tumors are significantly different in biological behavior and response to treatment. The past decade has witnessed advances in diagnosis and therapeutic modalities leading to improvements in survival. However, the optimal treatment for esthesioneuroblastoma, sinonasal undifferentiated carcinoma, and neuroendocrine carcinoma remain debated. We discuss advances in immunohistochemistry and molecular diagnosis, diagnostic strategies, and treatment selection. Conclusions There are significant differences in prognosis and treatment for esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma. Recent advances have the potential to improve oncologic outcomes but further investigation in needed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Int Arch Otorhinolaryngol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Int Arch Otorhinolaryngol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil