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Neonatal Pain and Infection Relate to Smaller Cerebellum in Very Preterm Children at School Age.
Ranger, Manon; Zwicker, Jill G; Chau, Cecil M Y; Park, Min Tae M; Chakravarthy, M Mallar; Poskitt, Kenneth; Miller, Steven P; Bjornson, Bruce H; Tam, Emily W Y; Chau, Vann; Synnes, Anne R; Grunau, Ruth E.
Afiliação
  • Ranger M; Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, British Columbia, Canada.
  • Zwicker JG; Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, British Columbia, Canada; Occupational Science and Occupational Therapy, University of British Columbia, Vancou
  • Chau CM; Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, British Columbia, Canada.
  • Park MT; Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada; Douglas Mental Health University Institute, Montreal, Quebec, Canada.
  • Chakravarthy MM; Douglas Mental Health University Institute, Montreal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
  • Poskitt K; Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, British Columbia, Canada.
  • Miller SP; Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada.
  • Bjornson BH; Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, British Columbia, Canada.
  • Tam EW; Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada.
  • Chau V; Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada.
  • Synnes AR; Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, British Columbia, Canada.
  • Grunau RE; Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, British Columbia, Canada. Electronic address: rgrunau@cw.bc.ca.
J Pediatr ; 167(2): 292-8.e1, 2015 Aug.
Article em En | MEDLINE | ID: mdl-25987534
OBJECTIVE: To examine whether specific neonatal factors differentially influence cerebellar subregional volumes and to investigate relationships between subregional volumes and outcomes in very preterm children at 7 years of age. STUDY DESIGN: Fifty-six children born very preterm (24-32 weeks gestational age) followed longitudinally from birth underwent 3-dimensional T(1)-weighted neuroimaging at median age 7.6 years. Children with severe brain injury were excluded. Cerebellar subregions were automatically segmented using the multiple automatically generated templates algorithm. The relation between cerebellum subregional volumes (adjusted for total brain volume and sex) and neonatal clinical factors were examined using constrained principal component analysis. Cognitive and visual-motor integration functions in relation to cerebellar volumes were also investigated. RESULTS: Higher neonatal procedural pain and infection, as well as other clinical factors, were differentially associated with reduced cerebellar volumes in specific subregions. After adjusting for clinical risk factors, neonatal procedural pain was distinctively associated with smaller volumes bilaterally in the posterior VIIIA and VIIIB lobules. Specific smaller cerebellar subregional volumes were related to poorer cognition and motor/visual integration. CONCLUSIONS: In very preterm children, exposure to painful procedures, as well as additional neonatal risk factors such as infection, were associated with reduced cerebellar volumes in specific subregions and poorer outcomes at school age.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Recém-Nascido Prematuro / Cerebelo / Infecções Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Child / Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Recém-Nascido Prematuro / Cerebelo / Infecções Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Child / Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos