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Transcranial direct current stimulation in obsessive-compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes.
Senço, Natasha M; Huang, Yu; D'Urso, Giordano; Parra, Lucas C; Bikson, Marom; Mantovani, Antonio; Shavitt, Roseli G; Hoexter, Marcelo Q; Miguel, Eurípedes C; Brunoni, André R.
Afiliação
  • Senço NM; Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
Expert Rev Med Devices ; 12(4): 381-91, 2015 Jul.
Article em En | MEDLINE | ID: mdl-25982412
BACKGROUND: Neuromodulation techniques for obsessive-compulsive disorder (OCD) treatment have expanded with greater understanding of the brain circuits involved. Transcranial direct current stimulation (tDCS) might be a potential new treatment for OCD, although the optimal montage is unclear. OBJECTIVE: To perform a systematic review on meta-analyses of repetitive transcranianal magnetic stimulation (rTMS) and deep brain stimulation (DBS) trials for OCD, aiming to identify brain stimulation targets for future tDCS trials and to support the empirical evidence with computer head modeling analysis. METHODS: Systematic reviews of rTMS and DBS trials on OCD in Pubmed/MEDLINE were searched. For the tDCS computational analysis, we employed head models with the goal of optimally targeting current delivery to structures of interest. RESULTS: Only three references matched our eligibility criteria. We simulated four different electrodes montages and analyzed current direction and intensity. CONCLUSION: Although DBS, rTMS and tDCS are not directly comparable and our theoretical model, based on DBS and rTMS targets, needs empirical validation, we found that the tDCS montage with the cathode over the pre-supplementary motor area and extra-cephalic anode seems to activate most of the areas related to OCD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Magnetoterapia / Estimulação Transcraniana por Corrente Contínua / Modelos Biológicos / Transtorno Obsessivo-Compulsivo Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Expert Rev Med Devices Assunto da revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Magnetoterapia / Estimulação Transcraniana por Corrente Contínua / Modelos Biológicos / Transtorno Obsessivo-Compulsivo Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Expert Rev Med Devices Assunto da revista: DIAGNOSTICO POR IMAGEM / TERAPEUTICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido