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Human Platelet Polymorphism can be a genetic marker associated with HIV/HCV coinfection.
Grotto, Rejane Maria Tommasini; Picelli, Natália; de Souza, Lenice do Rosário; Silva, Giovanni Faria; Ferrasi, Adriana Camargo; Silveira, Liciana Vaz de Arruda; Pardini, Maria Inês de Moura Campos.
Afiliação
  • Grotto RM; Molecular Biology Laboratory, Blood Transfusion Center, Botucatu Medical School, Sao Paulo State University, UNESP, São Paulo, Brazil.
  • Picelli N; Department of Bioprocess and Biotechnology, School of Agricultural Sciences, Lageado Experiment Station. Sao Paulo State University, UNESP, Botucatu-SP, Brazil.
  • de Souza Ldo R; Molecular Biology Laboratory, Blood Transfusion Center, Botucatu Medical School, Sao Paulo State University, UNESP, São Paulo, Brazil.
  • Silva GF; Tropical Diseases Department, Botucatu Medical School, Sao Paulo State University UNESP, São Paulo, Brazil.
  • Ferrasi AC; Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University UNESP, São Paulo, Brazil.
  • Silveira LV; Molecular Biology Laboratory, Blood Transfusion Center, Botucatu Medical School, Sao Paulo State University, UNESP, São Paulo, Brazil.
  • Pardini MI; Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University UNESP, São Paulo, Brazil.
J Med Virol ; 87(10): 1677-81, 2015 Oct.
Article em En | MEDLINE | ID: mdl-25976501
To evaluate the associations of HPA polymorphisms -1, -3, and -5 with HIV/HCV coinfection were included in this study 60 HIV/HCV-coinfected patients from the Sao Paulo State health service centers. Data reported by Verdichio-Moraes et al. (2009: J. Med Virol 81:757-759) were used as the non-infected and HCV monoinfected groups. Human Platelet Polymorphism genotyping was performed in 60 Patients co-infected with HIV/HCV by PCR-SSP or PCR-RFLP. HIV subtyping and HCV genotyping was performed by RT-PCR followed sequencing. The data analyses were performed using the χ2 test or Fisher's Exact Test and the logistic regression model. Patients coinfected with HIV/HCV presented HCV either genotype 1 (78.3%) or non-1 (21.7%) and HIV either subtype B (85.0%) or non-B (15%). The Human Platelet Polymorphism-1a/1b genotype was more frequent (P < 0.05) in HIV/HCV coinfection than in HCV monoinfection and the allelic frequency of Human Platelet Polymorphism-5b in the Patients coinfected with HIV/HCV was higher (P < 0.05) than in HCV monoinfected cases and non-infected individuals. These data suggest that the presence of specific HPA allele on platelets could favor the existence of coinfection. On the other hand, Human Platelet Polymorphism-5a/5b was more frequent (P < 0.05) in HIV/HCV coinfected and HCV monoinfected groups than in the non-infected individuals, suggesting that this platelet genotype is related to HCV infection, regardless of HIV presence. Results suggest that the Human Platelet Polymorphism profile in HIV/HCV coinfected individuals differs from the one of both HCV monoinfected and non-infected population. So, the Human Platelet Polymorphism can be a genetic marker associated with HIV/HCV coinfection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Infecções por HIV / Antígenos de Plaquetas Humanas / Hepatite C / Coinfecção Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Med Virol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Infecções por HIV / Antígenos de Plaquetas Humanas / Hepatite C / Coinfecção Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Med Virol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos