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TGF-ß1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients.
Ma, J; Liu, Y C; Fang, Y; Cao, Y; Liu, Z L.
Afiliação
  • Ma J; Department of Isotopic Laboratory, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
  • Liu YC; Department of Oncology, Taixing People's Hospital, Taixing, China.
  • Fang Y; Department of Central Laboratory, The Affiliated Fourth Hospital of Jiangsu University, Zhenjiang, China.
  • Cao Y; Department of Central Laboratory, The Affiliated Fourth Hospital of Jiangsu University, Zhenjiang, China.
  • Liu ZL; Department of Clinical Laboratory, The First People's Hospital of Lianyungang, Lianyungang, China 329391156@qq.com.
Genet Mol Res ; 14(2): 4461-8, 2015 May 04.
Article em En | MEDLINE | ID: mdl-25966218
Transforming growth factor-beta 1 (TGF-ß1), a member of the transforming growth factor beta family, functions as a multi-functional cytokine and plays a key role in cellular growth, proliferation, and differentiation. The 509 C/T polymorphism in the TGF-ß1 gene has been implicated in the outcome of hepatitis C virus (HCV) infection; however, little is known regarding the relationship between TGF-ß1 gene mutations and the development of hepatocellular carcinoma (HCC) in HCV-infected patients. The aim of the study was to evaluate the effect of the TGF-ß1 polymorphisms 509 C>T on the occurrence of HCC in patients chronically infected with HCV in a Chinese Han population. The results showed that HCC patients had a higher frequency of the TGF-ß1 -509 TT genotype distribution of the TGF-ß1 -509 polymorphism and a lower frequency of the CC genotype. Serum TGF-ß1 levels were significantly higher in patients with the TT genotype than in those with the CC genotype. In this study, we confirmed that the TGF-ß1 polymorphism 509 C>T is associated with the risk of HCC in HCV-infected patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Carcinoma Hepatocelular / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Fator de Crescimento Transformador beta1 / Neoplasias Hepáticas Tipo de estudo: Etiology_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C / Carcinoma Hepatocelular / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Fator de Crescimento Transformador beta1 / Neoplasias Hepáticas Tipo de estudo: Etiology_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil