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Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk.
Zhu, R; Bi, L Q; Kong, H; Tilley, S L; Wang, H; Xie, W P.
Afiliação
  • Zhu R; Department of Respiratory Medicine, The Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
  • Bi LQ; Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
  • Kong H; Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
  • Tilley SL; Pulmonary Immunobiology Laboratory, University of North Carolina, Chapel Hill, NC, USA.
  • Wang H; Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
  • Xie WP; Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China wpxie@njmu.edu.cn.
Genet Mol Res ; 14(2): 3590-600, 2015 Apr 17.
Article em En | MEDLINE | ID: mdl-25966127
Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence sarcoidosis susceptibility. The strength of the association between I/D polymorphisms and sarcoidosis risk was measured based on the odds ratio and 95% confidence interval. Analysis was based on recessive and dominant models. Ethnic subgroup analysis from 18 articles (1882 cases and 3066 controls) showed that DD homozygote carriers were at a slightly increased risk of sarcoidosis compared with II homozygotes and DI heterozygotes (P = 0.03). Comparison of DD plus DI vs II revealed no significant association with sarcoidosis in group and ethnic subgroup analysis. We found that the I/D polymorphism in the angiotensin-converting enzyme gene was not associated with a major risk of sarcoidosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Sarcoidose / Peptidil Dipeptidase A / Predisposição Genética para Doença Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Sarcoidose / Peptidil Dipeptidase A / Predisposição Genética para Doença Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil