Health and production traits in bovine are associated with single nucleotide polymorphisms in the NOD2 gene.
Genet Mol Res
; 14(2): 3570-8, 2015 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-25966125
The NOD2 gene plays a fundamental role in initiating the inflammatory and subsequent immune response. NOD2 was previously identified as a susceptibility locus for inflammatory bowel diseases in humans. In this study, we detected 2 mutations in exon 12 (AâT, GâA) among 5 cattle breeds (N = 315) and analyzed their associations with production traits and genetic resistance against bovine mastitis in Chinese Holstein and Chinese Simmental breeds (N = 218). The transitions (AâT) at position 114 bp were associated with somatic cell score (P < 0.01). The GâA at position 1594 bp plays a critical role in increasing 305-day milk yields. In Chinese Holstein and Chinese Simmental breeds, the BB genotype may contribute to disease susceptibility. Compared to all genotypic combinations, the A, B, and FF genotypes are beneficial not only for reducing somatic cell score but also for increasing production.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bovinos
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Leite
/
Proteína Adaptadora de Sinalização NOD2
/
Mastite Bovina
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Genet Mol Res
Assunto da revista:
BIOLOGIA MOLECULAR
/
GENETICA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Brasil