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Health and production traits in bovine are associated with single nucleotide polymorphisms in the NOD2 gene.
Wang, W; Cheng, L; Yi, J; Gan, J; Tang, H; Fu, M Z; Wang, H; Lai, S J.
Afiliação
  • Wang W; College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
  • Cheng L; Sichuan Animal Husbandry Station, Chengdu, Sichuan, China.
  • Yi J; Sichuan Animal Science Academy, Chengdu, Sichuan, China.
  • Gan J; Sichuan Animal Science Academy, Chengdu, Sichuan, China.
  • Tang H; Sichuan Animal Science Academy, Chengdu, Sichuan, China.
  • Fu MZ; Sichuan Animal Science Academy, Chengdu, Sichuan, China.
  • Wang H; Sichuan Animal Science Academy, Chengdu, Sichuan, China.
  • Lai SJ; College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China lsj5791@263.net.
Genet Mol Res ; 14(2): 3570-8, 2015 Apr 17.
Article em En | MEDLINE | ID: mdl-25966125
The NOD2 gene plays a fundamental role in initiating the inflammatory and subsequent immune response. NOD2 was previously identified as a susceptibility locus for inflammatory bowel diseases in humans. In this study, we detected 2 mutations in exon 12 (A→T, G→A) among 5 cattle breeds (N = 315) and analyzed their associations with production traits and genetic resistance against bovine mastitis in Chinese Holstein and Chinese Simmental breeds (N = 218). The transitions (A→T) at position 114 bp were associated with somatic cell score (P < 0.01). The G→A at position 1594 bp plays a critical role in increasing 305-day milk yields. In Chinese Holstein and Chinese Simmental breeds, the BB genotype may contribute to disease susceptibility. Compared to all genotypic combinations, the A, B, and FF genotypes are beneficial not only for reducing somatic cell score but also for increasing production.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bovinos / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Leite / Proteína Adaptadora de Sinalização NOD2 / Mastite Bovina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bovinos / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Leite / Proteína Adaptadora de Sinalização NOD2 / Mastite Bovina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil