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Participation of hMLH1, p63, and MDM2 proteins in the pathogenesis of syndromic and nonsyndromic keratocystic odontogenic tumors.
de Brito Monteiro, Bárbara Vanessa; Cavalcante, Roberta Barroso; Maia Nogueira, Renato Luiz; da Costa Miguel, Márcia Cristina; Weege Nonaka, Cassiano Francisco; da Silveira, Éricka Janine Dantas.
Afiliação
  • de Brito Monteiro BV; Postgraduate Program of Oral Pathology, Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
  • Cavalcante RB; Department of Oral Pathology, University of Fortaleza, Fortaleza, Ceara, Brazil.
  • Maia Nogueira RL; Department of Oral Surgery, Federal University of Ceara, Fortaleza, Ceara, Brazil.
  • da Costa Miguel MC; Postgraduate Program of Oral Pathology, Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
  • Weege Nonaka CF; Postgraduate Program of Dentistry, Department of Dentistry, State University of Paraiba, Campina Grande, Paraiba, Brazil.
  • da Silveira ÉJ; Postgraduate Program of Oral Pathology, Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address: Ericka_janine@yahoo.com.br.
Oral Surg Oral Med Oral Pathol Oral Radiol ; 120(1): 52-7, 2015 Jul.
Article em En | MEDLINE | ID: mdl-25957541
OBJECTIVES: To evaluate the expression of hMLH1, p63, and MDM2 in Gorlin syndrome-associated keratocystic odontogenic tumors (SKOTs) and nonsyndromic keratocystic odontogenic tumors (NSKOTs). STUDY DESIGN: Seventeen primary NSKOTs, 17 SKOTs, and 8 recurrent NSKOTs were analyzed by using immunohistochemistry. RESULTS: No significant differences in the hMLH1, p63, or MDM2 labeling indices were observed between groups (P = .398; P = .232; P = .426, respectively). Higher hMLH1 immunoexpression was found in the basal layer of primary NSKOTs. Most KOTs exhibited p63 immunoexpression in the upper layers of the epithelium. MDM2 immunoexpression was observed in the upper epithelial layers of SKOTs and recurrent NSKOTs. CONCLUSION: It was not possible to correlate the immunoexpression of hMLH1, p63, and MDM2 in SKOTs and primary and recurrent NSKOTs, suggesting that these proteins exert independent effects on the development of these groups of tumors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Síndrome do Nevo Basocelular / Tumores Odontogênicos / Proteínas Supressoras de Tumor / Proteínas Adaptadoras de Transdução de Sinal / Proteínas Proto-Oncogênicas c-mdm2 Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Oral Surg Oral Med Oral Pathol Oral Radiol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Síndrome do Nevo Basocelular / Tumores Odontogênicos / Proteínas Supressoras de Tumor / Proteínas Adaptadoras de Transdução de Sinal / Proteínas Proto-Oncogênicas c-mdm2 Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Oral Surg Oral Med Oral Pathol Oral Radiol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos