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Association of high-density lipoprotein and apolipoprotein E genetic variants with age-related macular degeneration.
Cezario, Sabrina Mayara; Calastri, Maria Clara Jéssica; Oliveira, Camila Ive Ferreira; Carmo, Tayanne Silva; Pinhel, Marcela Augusta de Souza; Godoy, Moacir Fernandes de; Jorge, Rodrigo; Cotrim, Carina Costa; Souza, Dorotéia Rossi Silva; Siqueira, Rubens Camargo.
Afiliação
  • Cezario SM; Medical School of São José do Rio Preto, São José do Rio Preto, SP, Brazil.
  • Calastri MC; Medical School of São José do Rio Preto, São José do Rio Preto, SP, Brazil.
  • Oliveira CI; Medical School of São José do Rio Preto, São José do Rio Preto, SP, Brazil.
  • Carmo TS; Medical School of São José do Rio Preto, São José do Rio Preto, SP, Brazil.
  • Pinhel MA; Medical School of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
  • Godoy MF; Medical School of São José do Rio Preto, São José do Rio Preto, SP, Brazil.
  • Jorge R; Department of Ophthalmology, Medical School of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
  • Cotrim CC; Department of Ophthalmology, Medical School of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
  • Souza DR; Medical School of São José do Rio Preto, São José do Rio Preto, SP, Brazil.
  • Siqueira RC; Medical School of São José do Rio Preto, São José do Rio Preto, SP, Brazil.
Arq Bras Oftalmol ; 78(2): 85-8, 2015.
Article em En | MEDLINE | ID: mdl-25945528
PURPOSE: This study aimed to evaluate the association of age-related macular degeneration (AMD) with apolipoprotein E (APOE) variants and serum lipid profiles, including levels and fractions of total serum cholesterol (TC), low-density lipoprotein cholesterol (LDLc), and high-density lipoprotein cholesterol (HDLc), and triglycerides (TG). METHODS: Genotyping of APOE-HhaI was performed in 134 patients (study group, SG) and 164 individuals without AMD (control group, CG), aged 50-89 years. Lipid profiles were analyzed in a subgroup of 30 subjects of both groups, matched according to age and sex. The significance level was set at P<0.05. RESULTS: APOE E3/E3 was more prevalent (SG=74.6%; CG=77.4%), with no difference between both groups (P=0.667). The same result was observed for risk genotypes (APOE E -/2: SG=7.4%; CG=10.3%, P=0.624). Serum levels of TC, LDLc, and TG revealed similar median values between SG (193.5, 116, and 155 mg/dL, respectively) and CG (207.5, 120, and 123.5 mg/dL, respectively; P >0.05). For HDLc, a higher median value was observed in SG (53.3 mg/dL) versus CG (42.5 mg/dL; P=0.016). Logistic regression analysis showed the same value, and the HDLc/TC ratio was -11.423 (P=0.014), as also confirmed by an increase in HDLc in SG. The association between lipid profiles and apolipoprotein E genotypes was similar in both groups (P>0.05). CONCLUSION: APOE-HhaI is not associated with AMD. However, an increase in serum HDLc level appears to exert a protective effect against the disease, irrespective of the genetic variants of apoE.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Lipoproteínas HDL / Degeneração Macular Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Bras Oftalmol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Lipoproteínas HDL / Degeneração Macular Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Bras Oftalmol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil