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Influence of ACTN3 R577X polymorphism on ventilatory thresholds related to endurance performance.
Pasqua, Leonardo A; Bueno, Salomão; Artioli, Guilherme G; Lancha, Antônio H; Matsuda, Monique; Marquezini, Mônica V; Lima-Silva, Adriano E; Saldiva, Paulo H N; Bertuzzi, Rômulo.
Afiliação
  • Pasqua LA; a Endurance Performance Research Group, School of Physical Education and Sport , University of São Paulo , São Paulo , SP , Brazil.
  • Bueno S; a Endurance Performance Research Group, School of Physical Education and Sport , University of São Paulo , São Paulo , SP , Brazil.
  • Artioli GG; b Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport , University of São Paulo , São Paulo , SP , Brazil.
  • Lancha AH; b Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport , University of São Paulo , São Paulo , SP , Brazil.
  • Matsuda M; c Faculty of Medicine , University of São Paulo , São Paulo , SP , Brazil.
  • Marquezini MV; d Laboratory of Experimental Air Pollution, Department of Pathology, Faculty of Medicine , University of São Paulo , São Paulo , SP , Brazil.
  • Lima-Silva AE; e Sport Science Research Group, Department of Physical Education and Sports Science (CAV) , Federal University of Pernambuco , Vitória de Santo Antão , PE , Brazil.
  • Saldiva PH; d Laboratory of Experimental Air Pollution, Department of Pathology, Faculty of Medicine , University of São Paulo , São Paulo , SP , Brazil.
  • Bertuzzi R; a Endurance Performance Research Group, School of Physical Education and Sport , University of São Paulo , São Paulo , SP , Brazil.
J Sports Sci ; 34(2): 163-70, 2016.
Article em En | MEDLINE | ID: mdl-25939605
The purpose of this study was to verify the association between ACTN3 polymorphism and physiological parameters related to endurance performance. A total of 150 healthy male volunteers performed a maximal incremental running test to determine the speeds corresponding to ventilatory threshold (VT) and respiratory compensation point (RCP). Participants were genotyped and divided into terciles based on the analysed variables. Genotype frequencies were compared through χ(2) test between lower and higher terciles, with the lowest or highest values of each analysed variable. ACTN3 XX genotype was over-represented in higher tercile for VT and RCP. Odds ratio also showed significantly higher chances of XX individuals to be in higher tercile compared to RR (7.3) and RR + RX (3.5) for VT and compared to RR genotype (8.1) and RR + RX (3.4) for RCP. Thus, XX individuals could attain the VT and RCP at higher speeds, suggesting that they are able to sustain higher running speeds in lower exercise intensity domains. It could result in higher lipid acids oxidation, saving muscle glycogen and delaying the fatigue during prolonged exercises, which could be the advantage mechanism of this genotype to endurance performance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência Física / Polimorfismo Genético / Actinina / Ventilação Pulmonar Limite: Humans / Male Idioma: En Revista: J Sports Sci Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência Física / Polimorfismo Genético / Actinina / Ventilação Pulmonar Limite: Humans / Male Idioma: En Revista: J Sports Sci Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido