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Atypical antipsychotics in the treatment of pathological aggression in children and adolescents: literature review and clinical recommendations.
Teixeira, Eduardo Henrique; Jacintho, Antonio; Celeri, Heloisa Valler; Dalgalarrondo, Paulo.
Afiliação
  • Teixeira EH; School of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil.
  • Jacintho A; Child and Adolescent Psychiatry Outpatient Unit, Hospital de Clínicas, Universidade Estadual de Campinas, Campinas, SP, Brazil.
  • Celeri HV; Child and Adolescent Psychiatry Outpatient Unit, HC, Unicamp, Campinas, SP, Brazil.
  • Dalgalarrondo P; Department of Medical Psychology and Psychiatry, School of Medical Sciences, UNICAMP, Campinas, SP, Brazil.
Trends Psychiatry Psychother ; 35(3): 151-9, 2013.
Article em En | MEDLINE | ID: mdl-25923387
OBJECTIVE: To review the literature about the use of atypical antipsychotics in the treatment of pathological aggression in children and adolescents. METHOD: The databases MEDLINE, SciELO, and LILACS were searched for publications in Portuguese or English from 1992 to August 2011 using the following keywords: mental disease, child, adolescent, treatment, atypical antipsychotic, aggressive behavior, aggression, and violent behavior. RESULTS: Sixty-seven studies of good methodological quality and clinical interest and relevance were identified. Studies including children and adolescents were relatively limited, because few atypical antipsychotics have been approved by the Food and Drug Administration (FDA). All the medications included in this review (risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole and clozapine) have some effectiveness in treating aggression in children and adolescents, and choices should be based on clinical indications and side effects. CONCLUSIONS: There are few studies about the effectiveness and safety of atypical antipsychotics for the pediatric population, and further randomized controlled studies with larger groups of patients and more diagnostic categories, such as severe conduct disorder and oppositional defiant disorder, should be conducted to confirm the results reported up to date and to evaluate the impact of long-term use.
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Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline / Systematic_reviews Idioma: En Revista: Trends Psychiatry Psychother Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline / Systematic_reviews Idioma: En Revista: Trends Psychiatry Psychother Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil