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Influence of sexual dimorphism on pulmonary inflammatory response in adult mice exposed to chloroform.
de Oliveira, Túlio Henrique Versiani; Campos, Keila Karine Duarte; Soares, Nícia Pedreira; Pena, Karina Braga; Lima, Wanderson Geraldo; Bezerra, Frank Silva.
Afiliação
  • de Oliveira TH; Graduating in Medicine, School of Medicine, Federal University of Ouro Preto (UFOP), Ouro Preto, Minas Gerais, Brazil.
  • Campos KK; Department of Biological Sciences (DECBI), Laboratory of Metabolic Biochemistry (LBM), Center of Research in Biological Sciences (NUPEB), Federal University of Ouro Preto (UFOP), Ouro Preto, Minas Gerais, Brazil.
  • Soares NP; Department of Biological Sciences (DECBI), Laboratory of Metabolic Biochemistry (LBM), Center of Research in Biological Sciences (NUPEB), Federal University of Ouro Preto (UFOP), Ouro Preto, Minas Gerais, Brazil.
  • Pena KB; Department of Biological Sciences (DECBI), Laboratory of Metabolic Biochemistry (LBM), Center of Research in Biological Sciences (NUPEB), Federal University of Ouro Preto (UFOP), Ouro Preto, Minas Gerais, Brazil.
  • Lima WG; Department of Biological Sciences (DECBI), Laboratory of Morphopathology (LMP), Center of Research in Biological Sciences (NUPEB), Federal University of Ouro Preto (UFOP), Ouro Preto, Minas Gerais, Brazil.
  • Bezerra FS; Department of Biological Sciences (DECBI), Laboratory of Metabolic Biochemistry (LBM), Center of Research in Biological Sciences (NUPEB), Federal University of Ouro Preto (UFOP), Ouro Preto, Minas Gerais, Brazil franksbezerra@hotmail.com.
Int J Toxicol ; 34(3): 250-7, 2015.
Article em En | MEDLINE | ID: mdl-25870144
Chloroform is an organic solvent used as an intermediate in the synthesis of various fluorocarbons. Despite its widespread use in industry and agriculture, exposure to chloroform can cause illnesses such as cancer, especially in the liver and kidneys. The aim of the study was to analyze the effects of chloroform on redox imbalance and pulmonary inflammatory response in adult C57BL/6 mice. Forty animals were divided into 4 groups (N = 10): female (FCG) and male (MCG) controls, and females (FEG) and males (MEG) exposed to chloroform (7.0 ppm) 3 times/d for 20 minutes for 5 days. Total and differential cell counts, oxidative damage analysis, and protein carbonyl and antioxidant enzyme catalase (CAT) activity measurements were performed. Morphometric analyses included alveolar area (Aa) and volume density of alveolar septa (Vv) measurements. Compared to FCG and MCG, inflammatory cell influx, oxidative damage to lipids and proteins, and CAT activity were higher in FEG and MEG, respectively. Oxidative damage and enzyme CAT activity were higher in FEG than in FCG. The Aa was higher in FEG and MEG than in FCG and MCG, respectively. The Vv was lower in FEG and MEG than in FCG and MCG, respectively. This study highlights the risks of occupational chloroform exposure at low concentrations and the intensity of oxidative damage related to gender. The results validate a model of acute exposure that provides cellular and biochemical data through short-term exposure to chloroform.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Alvéolos Pulmonares / Solventes / Carcinógenos / Clorofórmio / Estresse Oxidativo / Mucosa Respiratória Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / Alvéolos Pulmonares / Solventes / Carcinógenos / Clorofórmio / Estresse Oxidativo / Mucosa Respiratória Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos