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T(3) rapidly regulates several steps of alpha subunit glycoprotein (CGA) synthesis and secretion in the pituitary of male rats: Potential repercussions on TSH, FSH and LH secretion.
Bargi-Souza, Paula; Romano, Renata Marino; Goulart-Silva, Francemilson; Brunetto, Erika Lia; Nunes, Maria Tereza.
Afiliação
  • Bargi-Souza P; Department of Physiology and Biophysics of the Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
  • Romano RM; Department of Physiology and Biophysics of the Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
  • Goulart-Silva F; Department of Physiology and Biophysics of the Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
  • Brunetto EL; Department of Physiology and Biophysics of the Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
  • Nunes MT; Department of Physiology and Biophysics of the Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil. Electronic address: mtnunes@icb.usp.br.
Mol Cell Endocrinol ; 409: 73-81, 2015 Jul 05.
Article em En | MEDLINE | ID: mdl-25869399
TSH, FSH and LH share the same glycoprotein alpha chain (CGA) as part of their protein structure. Therefore, it is possible that thyroid and gonadal dysfunction may affect the CGA expression. This study evaluated several steps of CGA synthesis and secretion in thyrotrophs and gonadotrophs of control and hypothyroid rats, acutely or chronically-treated with T3. Hypothyroidism increased the Cga mRNA expression and its association to ribosome, but decreased intracellular CGA content. These parameters were reversed after acute or chronic T3 treatment. We conclude that T3 not only down-regulates Cga mRNA expression, as expected, but also inhibits the association of Cga mRNA to ribosome, as well as the CGA secretion. These findings add novel insights into our understanding of the role of T3 on the regulation of the Cga gene expression and CGA secretion, which might have a potential repercussion in all pituitary glycoprotein hormone synthesis and secretion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adeno-Hipófise / Tri-Iodotironina / Subunidade alfa de Hormônios Glicoproteicos / Hipotireoidismo Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adeno-Hipófise / Tri-Iodotironina / Subunidade alfa de Hormônios Glicoproteicos / Hipotireoidismo Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda