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Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of non-small cell lung cancer.
Hu, W X; Ding, C M; Li, R J; Fan, H Y; Guo, Z J; Liu, W.
Afiliação
  • Hu WX; Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
  • Ding CM; Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
  • Li RJ; Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
  • Fan HY; Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
  • Guo ZJ; Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
  • Liu W; Department of Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China 13933852787@163.com.
Genet Mol Res ; 14(1): 2512-7, 2015 Mar 30.
Article em En | MEDLINE | ID: mdl-25867397
The associations between single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) and cancer risk and disease outcome have been extensively analyzed. We investigated the association between age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of non-small cell lung cancer (NSCLC) patients. The D-loop region of mtDNA from NSCLC patients was amplified and sequenced. The age-at-onset curve of NSCLC patients was calculated using the Kaplan-Meier method at each SNP site and values were compared using the log-rank test. The SNP sites of nucleotides 200G/A and 16362T/C were identified to determine their association with age-at-onset of NSCLC using the log-rank test. The nucleotide 207G/A was identified for its association with age-at-onset at a borderline significance level (P = 0.060). We found that genetic polymorphisms in the D-loop were predictive markers for age-at-onset in NSCLC patients. Accordingly, the analysis of genetic polymorphisms in the mitochondrial D-loop can be used to identify NSCLC patient subgroups at high risk of early onset.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Carcinoma Pulmonar de Células não Pequenas / Polimorfismo de Nucleotídeo Único / Neoplasias Pulmonares Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Carcinoma Pulmonar de Células não Pequenas / Polimorfismo de Nucleotídeo Único / Neoplasias Pulmonares Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil