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Association between the LXRα polymorphism and stroke in a Chinese population.
Yang, J S; Hao, J J; Wang, S S; Zhu, Z F; Fang, Q; Bao, H; Zhang, H P.
Afiliação
  • Yang JS; Department of Neurology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangsu, China.
  • Hao JJ; Comprehensive Stroke Centre, Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China junjie_hao@yeah.net.
  • Wang SS; Comprehensive Stroke Centre, Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.
  • Zhu ZF; Department of Neurology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangsu, China.
  • Fang Q; Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
  • Bao H; Comprehensive Stroke Centre, Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.
  • Zhang HP; Department of Neurology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangsu, China.
Genet Mol Res ; 14(1): 1757-62, 2015 Mar 13.
Article em En | MEDLINE | ID: mdl-25867319
We examined the relationship between the liver X receptor α gene (LXRα) polymorphism and the susceptibility to stroke. We utilized the single fluorescent-labeled probe technique to detect the genotype of rs12221497 in the LXRα gene in 400 stroke patients and 400 healthy control subjects. The difference in genotype distribution between the 2 groups was analyzed using the chi-square test. Serum lipids and glucose levels between the different genotypes were also compared. We found that the risk of stroke in carriers with the AA + GA genotype was 2.02-fold higher than that in GG genotype carriers (odds ratio = 2.02, 95% confidence interval = 1.18-2.87, P < 0.05), and that the risk of stroke in carriers with the A allele increased by 0.606-fold compared to that in G allele carriers (odds ratio = 1.606, 95% confidence interval = 1.158-2.228). Logistic regression analysis showed that after adjusting for other confounding factors, the A allele was an independent risk for stroke. However, there were no differences in serum lipids and glucose levels between each genotype. We conclude that the rs12221497 polymorphism in the LXRα gene was associated with the susceptibility to stroke in a Han Chinese population.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral / Povo Asiático / Receptores Nucleares Órfãos Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral / Povo Asiático / Receptores Nucleares Órfãos Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China País de publicação: Brasil