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Influenza virus prevalence in asymptomatic and symptomatic subjects during pandemic and postpandemic periods.
Melchior, Thaís Boim; Perosa, Ana Helena; Camargo, Clarice Neves; Granato, Celso; Bellei, Nancy.
Afiliação
  • Melchior TB; Clinical Virology Laboratory - Infectious Disease Unit, Medicine Department, Federal University of Sao Paulo, SP, Brazil.
  • Perosa AH; Clinical Virology Laboratory - Infectious Disease Unit, Medicine Department, Federal University of Sao Paulo, SP, Brazil. Electronic address: anaperosa@gmail.com.
  • Camargo CN; Clinical Virology Laboratory - Infectious Disease Unit, Medicine Department, Federal University of Sao Paulo, SP, Brazil.
  • Granato C; Clinical Virology Laboratory - Infectious Disease Unit, Medicine Department, Federal University of Sao Paulo, SP, Brazil.
  • Bellei N; Clinical Virology Laboratory - Infectious Disease Unit, Medicine Department, Federal University of Sao Paulo, SP, Brazil.
Am J Infect Control ; 43(5): 460-4, 2015 May 01.
Article em En | MEDLINE | ID: mdl-25792101
BACKGROUND: In 2009, Influenza A(H1N1)pdm09 had a major effect on global health, causing thousands of deaths. However, the results of asymptomatic infection in transmission has not been well studied. We analyzed asymptomatic influenza infection in individuals with different risk factors for acquiring influenza in a university hospital. METHODS: Respiratory samples from 100 children with respiratory symptoms, their asymptomatic caregivers, 100 asymptomatic HIV-infected patients, and 100 health care workers collected during 2009-2011 were tested for influenza by real time real-time polymerase chain reaction. RESULTS: Influenza infection rate in symptomatic children was 44% and in asymptomatic adults it was 8.3% (P < .01). Children older than age 5 years had a 3.4 times greater chance of being infected during influenza season than younger children. Among the asymptomatic group, influenza was more frequent in caregivers (14%; P = .032) and a higher rate (31.8%) was observed if a child was infected during the 2009 pandemic. Contact with an infected child was an important risk factor for influenza acquisition (odds ratio, 3.8; 95% confidence interval, 1.1-13.2) among caregivers. The mean cluster of differentiation 4 T-cell count of HIV-positive patients infected with influenza was not statistically different from uninfected patients (P = .29). CONCLUSIONS: Asymptomatic household contacts of symptomatic children may play an important role in community transmission and a more proactive intervention should be considered during future pandemics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orthomyxoviridae / Influenza Humana / Doenças Assintomáticas / Pandemias Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Am J Infect Control Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orthomyxoviridae / Influenza Humana / Doenças Assintomáticas / Pandemias Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Am J Infect Control Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos