A new mononuclear manganese(III) complex of an unsymmetrical hexadentate N3O3 ligand exhibiting superoxide dismutase and catalase-like activity: synthesis, characterization, properties and kinetics studies.
J Inorg Biochem
; 146: 69-76, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25771435
A mononuclear Mn(III) complex MnL·4H2O (H3L=1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N'-(2-hydroxybenzyl),N'-(4-methylbenzyl)amino]propan-2-ol) has been prepared and characterized. This complex catalyzes the dismutation of superoxide efficiently, with catalytic rate constant kcat=1.7×10(6)M(-1)s(-1) and IC50 1.26µM, obtained through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH7.8. MnL is also able to disproportionate more than 300 equivalents of H2O2 in CH3CN, with initial rate of H2O2 decomposition given by ri=kcat [MnL](2) [H2O2] and kcat=1.32(2)mM(-2)min(-1). The accessibility of the Mn(IV) state (E(p)=0.53V vs. saturated calomel electrode), suggests MnL employs a high-valent catalytic cycle to decompose O2(-) and H2O2.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Propanolaminas
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Piridinas
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Compostos de Manganês
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Complexos de Coordenação
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Peróxido de Hidrogênio
Idioma:
En
Revista:
J Inorg Biochem
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Estados Unidos