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Trypanosoma cruzi necrotizing meningoencephalitis in a Venezuelan HIV⁺-AIDS patient: pathological diagnosis confirmed by PCR using formalin-fixed- and paraffin-embedded-tissues.
Rossi Spadafora, Marcello Salvatore; Céspedes, Ghislaine; Romero, Sandra; Fuentes, Isabel; Boada-Sucre, Alpidio A; Cañavate, Carmen; Flores-Chávez, María.
Afiliação
  • Rossi Spadafora MS; Unit of Toxoplasmosis and Intestinal Protozoosis, Department of Parasitology, National Centre for Microbiology, Carlos III Health Institute, Carretera de Majadahonda-Pozuelo Km 22, Majadahonda, 28220 Madrid, Spain ; Section of Research on Ultrastructural Pathology and Molecular Biology, José A. O'Da
  • Céspedes G; Section of Neuropathology, José A. O'Daly Institute for Pathology, Faculty of Medicine, Central University of Venezuela, Caracas 1080-A, Venezuela.
  • Romero S; Section of Nephropathology, José A. O'Daly Institute for Pathology, Faculty of Medicine, Central University of Venezuela, Caracas 1080-A, Venezuela.
  • Fuentes I; Unit of Toxoplasmosis and Intestinal Protozoosis, Department of Parasitology, National Centre for Microbiology, Carlos III Health Institute, Carretera de Majadahonda-Pozuelo Km 22, Majadahonda, 28220 Madrid, Spain.
  • Boada-Sucre AA; Laboratory of Electron Microscopy, Institute of Scientific and Technological Studies, Simón Rodríguez University, Caracas 1041-A, Venezuela.
  • Cañavate C; Unit of Leishmaniasis and Chagas Disease Diagnosis, Department of Parasitology, National Centre for Microbiology, Carlos III Health Institute, Carretera de Majadahonda-Pozuelo Km 22, Majadahonda, 28220 Madrid, Spain.
  • Flores-Chávez M; Unit of Leishmaniasis and Chagas Disease Diagnosis, Department of Parasitology, National Centre for Microbiology, Carlos III Health Institute, Carretera de Majadahonda-Pozuelo Km 22, Majadahonda, 28220 Madrid, Spain.
Anal Cell Pathol (Amst) ; 2014: 124795, 2014.
Article em En | MEDLINE | ID: mdl-25763312
Coinfections with human immunodeficiency virus (HIV) and infectious agents have been recognized since the early 90s. In the central nervous system (CNS) of HIV(+) patients, parasitic protozoans like Toxoplasma gondii have been described as responsible for the space occupying lesions (SOL) developed. However, the involvement of Trypanosoma cruzi is also described but appears to be less frequent in acquired immunodeficiency syndrome (AIDS) and transplant recipients, associated with necrotizing myocarditis and neurological symptoms related to the occurrence of necrotizing pseudotumoral encephalitis (NPE) and meningoencephalitis (NME). The present work aims to present a Venezuelan case of NME associated with the coinfection of HIV and a T. cruzi-like trypanosomatid as well as its evolution and diagnosis by histopathological techniques, electron microscopy, and PCR methods using formalin-fixed- (FF-) and paraffin-embedded- (PE-) tissues. Postmortem cytological studies of leptomeninges imprints reveal the presence of trypomastigotes of Trypanosoma sp. Histopathological and electron microscopy studies allowed us to identify an amastigote stage and to reject the involvement of other opportunistic microorganisms as the etiological agent of the SOL. The definitive confirmation of T. cruzi as the etiological agent was achieved by PCR suggesting that the NME by T. cruzi was due to a reactivation of Chagas' disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome da Imunodeficiência Adquirida / Doença de Chagas / Meningoencefalite Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Humans / Male País/Região como assunto: America do sul / Venezuela Idioma: En Revista: Anal Cell Pathol (Amst) Assunto da revista: NEOPLASIAS / PATOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome da Imunodeficiência Adquirida / Doença de Chagas / Meningoencefalite Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Humans / Male País/Região como assunto: America do sul / Venezuela Idioma: En Revista: Anal Cell Pathol (Amst) Assunto da revista: NEOPLASIAS / PATOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos