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Intrauterine Growth Restricted Rats Exercised at Pregnancy: Maternal-Fetal Repercussions.
Corvino, S B; Netto, A O; Sinzato, Y K; Campos, K E; Calderon, I M P; Rudge, M V C; Volpato, G T; Zambrano, E; Damasceno, D C.
Afiliação
  • Corvino SB; Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
  • Netto AO; Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
  • Sinzato YK; Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
  • Campos KE; Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil Institute of Biological and Health Sciences, University Center of Araguaia, Mato Grosso Fe
  • Calderon IM; Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
  • Rudge MV; Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
  • Volpato GT; Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil Institute of Biological and Health Sciences, University Center of Araguaia, Mato Grosso Fe
  • Zambrano E; Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador, Zubirán, Mexico.
  • Damasceno DC; Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil damascenofmb@gmail.com.
Reprod Sci ; 22(8): 991-9, 2015 Aug.
Article em En | MEDLINE | ID: mdl-25761405
To evaluate the effect of swimming in pregnant rats born with intrauterine growth restriction (IUGR) and their offspring, IUGR rats were obtained using the streptozotocin-induced severe diabetic (SD) rats. In this study, the nondiabetic parental generation presented 10 rats and diabetic parental generation presented 116 rats. Of these, the mated nondiabetic female rats were 10 and the number of diabetic rats was 45. In relation to term pregnancy, there were 10 animals in the nondiabetic group and 15 rats in the diabetic group. In the offspring of SD rats (IUGR group), 43 females were classified as small for pregnancy age, 19 rats were classified as appropriate for pregnancy age, and 0 female was classified as large for pregnancy age. The nondiabetic and SD pregnant rats generated offspring with appropriate (control [C]) and small (IUGR) weight for pregnancy age, respectively. At adult life, the C group was maintained as nonexercised C group and IUGR rats were distributed into 2 subgroups, namely, nonexercised (IUGR) and exercised (IUGRex). The rate of mated rats in the IUGR group was reduced compared to the C group. During pregnancy, the IUGR rats presented hyperinsulinemia, impaired reproductive outcomes, decreased body weight, hypertriglyceridemia, and hyperlactacidemia. The IUGRex presented reduced insulin and triglyceride levels. Thus, swimming improved lipid metabolism and increased insulin sensitivity. However, the offspring showed retarded growth, reinforcing the need to stimulate the exercise practice in women under supervision with different professional expertise to promote appropriate gestational conditions and improve perinatal outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Reprodução / Natação / Diabetes Mellitus Experimental / Esforço Físico / Retardo do Crescimento Fetal Tipo de estudo: Etiology_studies Limite: Animals / Pregnancy Idioma: En Revista: Reprod Sci Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Reprodução / Natação / Diabetes Mellitus Experimental / Esforço Físico / Retardo do Crescimento Fetal Tipo de estudo: Etiology_studies Limite: Animals / Pregnancy Idioma: En Revista: Reprod Sci Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos