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Enzymatic activities linked to cardiac energy metabolism of Trypanosoma evansi-infected rats and their possible functional correlations to disease pathogenesis.
Baldissera, Matheus D; Rech, Virginia C; Grings, Mateus; Gressler, Lucas T; Vaucher, Rodrigo A; Schwertz, Claiton I; Mendes, Ricardo E; Leipnitz, Guilhian; Stefani, Lenita M; Monteiro, Silvia G; da Silva, Aleksandro S.
Afiliação
  • Baldissera MD; Department of Microbiology and Parasitology,Universidade Federal de Santa Maria (UFSM),Santa Maria,RS,Brazil.
  • Rech VC; Laboratory of Nanotechnology,Centro Universitário Franciscano,Santa Maria,RS,Brazil.
  • Grings M; Department of Biochemistry,Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS),Porto Alegre,RS,Brazil.
  • Gressler LT; Department of Microbiology and Parasitology,Universidade Federal de Santa Maria (UFSM),Santa Maria,RS,Brazil.
  • Vaucher RA; Laboratory of Microbiology,Centro Universitário Franciscano,Santa Maria,RS,Brazil.
  • Schwertz CI; Section of Veterinary Pathology,Instituto Federal Catarinense,Concórdia,SC,Brazil.
  • Mendes RE; Section of Veterinary Pathology,Instituto Federal Catarinense,Concórdia,SC,Brazil.
  • Leipnitz G; Department of Biochemistry,Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS),Porto Alegre,RS,Brazil.
  • Stefani LM; Department of Animal Science,Universidade do Estado de Santa Catarina (UDESC),Chapecó,SC,Brazil.
  • Monteiro SG; Department of Microbiology and Parasitology,Universidade Federal de Santa Maria (UFSM),Santa Maria,RS,Brazil.
  • da Silva AS; Department of Animal Science,Universidade do Estado de Santa Catarina (UDESC),Chapecó,SC,Brazil.
Parasitology ; 142(9): 1163-70, 2015 Aug.
Article em En | MEDLINE | ID: mdl-25758981
The aim of this study was to investigate the activities of important enzymes involved in the phosphoryl transfer network (adenylate kinase and creatine kinase (CK)), lactate dehydrogenase (LDH), respiratory chain complexes and biomarkers of cardiac function in rat experimentally infected by Trypanosoma evansi. Rat heart samples were evaluated at 5 and 15 days post-infection (PI). At 5 day PI, there was an increase in LDH and CK activities, and a decrease in respiratory chain complexes II, IV and succinate dehydrogenase activities. In addition, on day 15 PI, a decrease in the respiratory chain complex IV activity was observed. Biomarkers of cardiac function were higher in infected animals on days 5 and 15 PI. Considering the importance of the energy metabolism for heart function, it is possible that the changes in the enzymatic activities involved in the cardiac phosphotransfer network and the decrease in respiratory chain might be involved partially in the role of biomarkers of cardiac function of T. evansi-infected rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma / Tripanossomíase / Regulação Enzimológica da Expressão Gênica / Metabolismo Energético / Miocárdio Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Parasitology Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma / Tripanossomíase / Regulação Enzimológica da Expressão Gênica / Metabolismo Energético / Miocárdio Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Parasitology Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido