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Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study.
Luetkemeyer, Anne F; Rosenkranz, Susan L; Lu, Darlene; Grinsztejn, Beatriz; Sanchez, Jorge; Ssemmanda, Michael; Sanne, Ian; McIlleron, Helen; Havlir, Diane V; Haas, David W.
Afiliação
  • Luetkemeyer AF; HIV/AIDS Division, San Francisco General Hospital, University of California, San Francisco.
  • Rosenkranz SL; Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts.
  • Lu D; Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts.
  • Grinsztejn B; Fundacao Oswaldo Cruz, Instituto de Pesquisa Clinica Evandro Chagas, Rio de Janeiro, Brazil.
  • Sanchez J; IMPACTA, Lima, Peru.
  • Ssemmanda M; Joint Clinical Research Center, Kampala, Uganda.
  • Sanne I; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg.
  • McIlleron H; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa.
  • Havlir DV; HIV/AIDS Division, San Francisco General Hospital, University of California, San Francisco.
  • Haas DW; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Clin Infect Dis ; 60(12): 1860-3, 2015 Jun 15.
Article em En | MEDLINE | ID: mdl-25722197
In STRIDE, slow metabolizer CYP2B6 and NAT2 genotypes were each associated with increased plasma efavirenz concentrations during antituberculosis therapy. Concentrations were greater on therapy than off therapy in 58% with CYP2B6 and 93% with NAT2 slow metabolizer genotypes. Individuals with slow metabolizer genotypes in both genes had markedly elevated concentrations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arilamina N-Acetiltransferase / Rifampina / Tuberculose / Benzoxazinas / Citocromo P-450 CYP2B6 / Antituberculosos Limite: Female / Humans / Male País/Região como assunto: Africa / America do sul / Peru Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arilamina N-Acetiltransferase / Rifampina / Tuberculose / Benzoxazinas / Citocromo P-450 CYP2B6 / Antituberculosos Limite: Female / Humans / Male País/Região como assunto: Africa / America do sul / Peru Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos