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Effects of conventional vs high-dose rocuronium on the QTc interval during anesthesia induction and intubation in patients undergoing coronary artery surgery: a randomized, double-blind, parallel trial.
Öztürk, T; Agdanli, D; Bayturan, Ö; Çikrikci, C; Keles, G T.
Afiliação
  • Öztürk T; Department of Anesthesiology and Reanimation, School of Medicine, Celal Bayar University, Manisa, Turkey.
  • Agdanli D; Department of Anesthesiology and Reanimation, School of Medicine, Celal Bayar University, Manisa, Turkey.
  • Bayturan Ö; Department of Cardiology, School of Medicine, Celal Bayar University, Manisa, Turkey.
  • Çikrikci C; Department of Anesthesiology and Reanimation, School of Medicine, Celal Bayar University, Manisa, Turkey.
  • Keles GT; Department of Anesthesiology and Reanimation, School of Medicine, Celal Bayar University, Manisa, Turkey.
Braz J Med Biol Res ; 48(4): 370-6, 2015 Apr.
Article em En | MEDLINE | ID: mdl-25714880
Myocardial ischemia, as well as the induction agents used in anesthesia, may cause corrected QT interval (QTc) prolongation. The objective of this randomized, double-blind trial was to determine the effects of high- vs conventional-dose bolus rocuronium on QTc duration and the incidence of dysrhythmias following anesthesia induction and intubation. Fifty patients about to undergo coronary artery surgery were randomly allocated to receive conventional-dose (0.6 mg/kg, group C, n=25) or high-dose (1.2 mg/kg, group H, n=25) rocuronium after induction with etomidate and fentanyl. QTc, heart rate, and mean arterial pressure were recorded before induction (T0), after induction (T1), after rocuronium (just before laryngoscopy; T2), 2 min after intubation (T3), and 5 min after intubation (T4). The occurrence of dysrhythmias was recorded. In both groups, QTc was significantly longer at T3 than at baseline [475 vs 429 ms in group C (P=0.001), and 459 vs 434 ms in group H (P=0.005)]. The incidence of dysrhythmias in group C (28%) and in group H (24%) was similar. The QTc after high-dose rocuronium was not significantly longer than after conventional-dose rocuronium in patients about to undergo coronary artery surgery who were induced with etomidate and fentanyl. In both groups, compared with baseline, QTc was most prolonged at 2 min after intubation, suggesting that QTc prolongation may be due to the nociceptive stimulus of intubation.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuromusculares não Despolarizantes / Vasos Coronários / Eletrocardiografia / Androstanóis / Intubação / Anestesia Geral Tipo de estudo: Clinical_trials / Etiology_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Neuromusculares não Despolarizantes / Vasos Coronários / Eletrocardiografia / Androstanóis / Intubação / Anestesia Geral Tipo de estudo: Clinical_trials / Etiology_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Med Biol Res Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil