Subconjunctival and topical application of recombinant tissue plasminogen activator in rabbits.
Arq Bras Oftalmol
; 78(1): 6-9, 2015.
Article
em En
| MEDLINE
| ID: mdl-25714529
PURPOSE: To quantify fibrin degradation products after topical and subconjunctival administration of recombinant tissue plasminogen activator in rabbits. METHODS: Fibrin formation was induced in the anterior chamber in 25 rabbits. Subsequently, five rabbits received an injection of r-TPA (positive control) in the anterior chamber, another 10 received a subconjunctival injection of r-TPA, and the remaining 10 received instillations of topical r-TPA. Afterwards, samples of aqueous humor were collected and semi-quantitative analysis of fibrin degradation products (FDP) was performed. RESULTS: No statistical differences were noted between the treatment and control groups at any time point. Fibrin degradation products semi-quantification showed statistical improvement in the control group and the subconjunctival group. CONCLUSION: Fibrin degradation products were observed in the anterior chamber after subconjunctival administration of r-TPA. However, it was probably not sufficient to cause fibrin degradation. Topical r-TPA did not effectively absorb anterior chamber fibrin.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Humor Aquoso
/
Produtos de Degradação da Fibrina e do Fibrinogênio
/
Ativador de Plasminogênio Tecidual
/
Câmara Anterior
Tipo de estudo:
Observational_studies
Limite:
Animals
Idioma:
En
Revista:
Arq Bras Oftalmol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil