Nuclear architecture and gene silencing in olfactory sensory neurons.
Bioarchitecture
; 4(4-5): 160-3, 2014.
Article
em En
| MEDLINE
| ID: mdl-25714005
Odorants are discriminated by hundreds of odorant receptor (OR) genes, which are dispersed throughout the mammalian genome. The OR genes are expressed in a highly specialized type of cell, the olfactory sensory neuron. Each one of these neurons expresses one of the 2 alleles from one single OR gene type. The mechanisms underlying OR gene expression are unclear. Here we describe recent work demonstrating that the olfactory sensory neuron shows a particular nuclear architecture, and that the genomic OR loci are colocalized in silencing heterochromatin compartments within the nucleus. These discoveries highlight the important role played by epigenetic modifications and nuclear genome organization in the regulation of OR gene expression.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Heterocromatina
/
Núcleo Celular
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Regulação da Expressão Gênica
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Receptores Odorantes
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Neurônios Receptores Olfatórios
/
Alelos
Limite:
Animals
Idioma:
En
Revista:
Bioarchitecture
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos