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Histologic effect of a postnatal slow-release GnRH agonist on feline gonads.
Carranza, A; Faya, M; Fernandez, P; Barbeito, C; Gobello, C.
Afiliação
  • Carranza A; Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata- CONICET, La Plata, Argentina.
  • Faya M; Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata- CONICET, La Plata, Argentina.
  • Fernandez P; Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata- CONICET, La Plata, Argentina.
  • Barbeito C; Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata- CONICET, La Plata, Argentina.
  • Gobello C; Laboratory of Reproductive Physiology, Faculty of Veterinary Medicine, National University of La Plata- CONICET, La Plata, Argentina. Electronic address: cgobello@fcv.unlp.edu.ar.
Theriogenology ; 83(8): 1368-72, 2015 May.
Article em En | MEDLINE | ID: mdl-25707328
In postnatal domestic cats, GnRH agonists suppressed fecal concentrations of sexual steroids and delayed puberty. The aim of this study was to describe the gross and microscopic morphometric effects of a single administration of the GnRH agonist, deslorelin acetate, on the gonads of postnatally treated cats. Twenty-seven postnatal male (n = 14) and female (n = 13) kittens were randomly assigned to one of the following treatment groups within the first 24 hours of birth: deslorelin acetate (1.6 mg, subcutaneous; DA, n = 16) or control that remained untreated (CO, n = 11) and spayed or castrated immediately after the onset of puberty. After surgical removal, the gonads were gross and histologically assessed. Sertoli cells also were examined immunohistochemically. Comparisons between the treatments were carried out by the Student t test. Gross gonadal wet weight and volume as well as gonadosomatic index were significantly lower in the DA than those in the CO males; these same parameters were not different in females. Primordial (461.4 + 3.0 vs. 1074.3 + 117.5; P < 0.01), primary (59.1 + 13.5 vs. 165.4 + 24.6; P < 0.01), and secondary (17.5 + 2.6 vs. 31.17 + 8.1; P < 0.05) follicles per mm(2) were decreased in DA than in CO gonads. Epididymal sperm motility and morphology were normal in all but two DA cats that had too few sperm to be evaluated. Germinal epithelial height (µm; 39.68 + 0.92 vs. 72.7 + 1.2; P < 0.01) and most of their cellular components as well as the Sertoli (cm(3); 0.1 + 0.02 vs. 0.24 + 0.05; P < 0.01) cells were diminished in the DA cats. Gonadotropin-releasing hormone agonist endocrine disruption during the neonatal critical reproductive time window may have a potential as a contraceptive agent in domestic felids.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ovário / Testículo / Gatos / Hormônio Liberador de Gonadotropina / Pamoato de Triptorrelina / Animais Recém-Nascidos Limite: Animals Idioma: En Revista: Theriogenology Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ovário / Testículo / Gatos / Hormônio Liberador de Gonadotropina / Pamoato de Triptorrelina / Animais Recém-Nascidos Limite: Animals Idioma: En Revista: Theriogenology Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos