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Relationship between blood metals and inflammation in taxi drivers.
Brucker, Natália; Moro, Angela; Charão, Mariele; Bubols, Guilherme; Nascimento, Sabrina; Goethel, Gabriela; Barth, Anelise; Prohmann, Ana C; Rocha, Rafael; Moresco, Rafael; Sangoi, Manuela; Hausen, Bruna S; Saint'Pierre, Tatiana; Gioda, Adriana; Duarte, Marta; Castro, Iran; Saldiva, Paulo H; Garcia, Solange Cristina.
Afiliação
  • Brucker N; Laboratory of Toxicology, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Moro A; Laboratory of Toxicology, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Charão M; Laboratory of Toxicology, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Bubols G; Laboratory of Toxicology, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Nascimento S; Laboratory of Toxicology, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Goethel G; Laboratory of Toxicology, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Barth A; Laboratory of Toxicology, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Prohmann AC; Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Department of Chemistry, Rio de Janeiro, RJ, Brazil.
  • Rocha R; Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Department of Chemistry, Rio de Janeiro, RJ, Brazil.
  • Moresco R; Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Federal University of Santa Maria, Santa Maria, RS, Brazil.
  • Sangoi M; Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Federal University of Santa Maria, Santa Maria, RS, Brazil.
  • Hausen BS; Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, Federal University of Santa Maria, Santa Maria, RS, Brazil.
  • Saint'Pierre T; Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Department of Chemistry, Rio de Janeiro, RJ, Brazil.
  • Gioda A; Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Department of Chemistry, Rio de Janeiro, RJ, Brazil.
  • Duarte M; Department of Health Sciences, Lutheran University of Brazil, Santa Maria, RS, Brazil.
  • Castro I; Institute of Cardiology, University Cardiology Foundation, Porto Alegre, RS, Brazil.
  • Saldiva PH; Department of Pathology, College of Medicine, University of São Paulo, São Paulo, SP, Brazil.
  • Garcia SC; Laboratory of Toxicology, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Post-graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Institute of Cardiology, University Car
Clin Chim Acta ; 444: 176-81, 2015 Apr 15.
Article em En | MEDLINE | ID: mdl-25704304
BACKGROUND: Cardiovascular disease is a cause of concern in public health worldwide, reinforcing the need for studies related to the identification of potential agents that contribute to the inflammation process and atherosclerosis. This study aimed to evaluate whether metals are associated with inflammatory and kidney damage and could contribute to the atherosclerosis process. METHODS: Blood metals, inflammatory markers, homocysteine, antioxidants and renal markers were measured in 42 taxi drivers and 27 controls (non-occupationally exposed). RESULTS: Taxi drivers had increased Hg, As, Pb and Cd levels, however Cu and Zn levels were decreased compared to controls (p<0.05). Hg, As and Pb levels were positively associated with pro-inflammatory cytokines, nitric oxide and negatively associated with glutathione peroxidase. Moreover, Hg, As and Pb presented positive associations with homocysteine, an independent risk factor for atherosclerosis. Regarding markers of kidney function, N-acetyl-beta-d-glucosaminidase levels were increased in taxi drivers and correlated to inflammation markers. CONCLUSION: Hg levels were found above the recommended limits in taxi drivers and both Hg and As levels showed associations with inflammatory process, oxidative status and homocysteine. Thus, chemical substances as Hg and As can be considered as additional contributors to the development of cardiovascular diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arsênio / Condução de Veículo / Cádmio / Inflamação / Chumbo / Mercúrio Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Clin Chim Acta Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arsênio / Condução de Veículo / Cádmio / Inflamação / Chumbo / Mercúrio Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Clin Chim Acta Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda