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Dealing with bone marrow biopsies in the staging of classical Hodgkin lymphoma: an old issue revisited in the (18)F-fluorodeoxyglucose-positron emission tomography era.
Gonçalves, Marianne de Castro; de Paula, Henrique Moura; Linardi, Camila da Cruz Gouveia; Cerci, Juliano J; Aldred, Vera Lucia; Siqueira, Sheila Aparecida Coelho; Buccheri, Valeria; Zerbini, Maria Claudia Nogueira.
Afiliação
  • Gonçalves Mde C; a Pathology, Clinics Hospital, University of Sao Paulo Medical School , Sao Paulo , Brazil.
  • de Paula HM; b Pathology, University of Goias Medical School , Goiania , Brazil.
  • Linardi Cda C; c Hematology, Clinics Hospital, University of Sao Paulo Medical School , Sao Paulo , Brazil.
  • Cerci JJ; d Division of PET/CT, Quanta - Diagnóstico Nuclear , Curitiba , Brazil.
  • Aldred VL; e Pathology, University of São Paulo , São Paulo , Brazil.
  • Siqueira SA; a Pathology, Clinics Hospital, University of Sao Paulo Medical School , Sao Paulo , Brazil.
  • Buccheri V; c Hematology, Clinics Hospital, University of Sao Paulo Medical School , Sao Paulo , Brazil.
  • Zerbini MC; a Pathology, Clinics Hospital, University of Sao Paulo Medical School , Sao Paulo , Brazil.
Leuk Lymphoma ; 56(10): 2883-8, 2015.
Article em En | MEDLINE | ID: mdl-25697914
Bone marrow biopsy is recommended for staging of classical Hodgkin lymphoma. The aim of this study was to compare bone marrow evaluation by histology with that obtained by (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET). One hundred and three cases of Classical Hodgkin Lymphoma were reviewed. All patients were submitted to FDG-PET evaluation. Bone marrow biopsy results were compared with clinical data and FDG-PET results. Ninety-one cases had available bone marrow biopsies. Overall, there were 16 positive and one suspect case. In five cases, the FDG-PET scan was positive and biopsy was negative: 1/5 was found to correspond to a bone fracture, 3/5 showed marked reactive bone marrow changes and in 1/5 no explanation for the discrepancy was found. FDG-PET showed high sensitivity, supporting the idea that when it is negative, biopsy could be avoided. Care should be taken in patients with a positive FDG-PET, where confirmation by bone marrow biopsy should be recommended.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Óssea / Doença de Hodgkin / Fluordesoxiglucose F18 / Tomografia por Emissão de Pósitrons Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Lymphoma Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Óssea / Doença de Hodgkin / Fluordesoxiglucose F18 / Tomografia por Emissão de Pósitrons Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Lymphoma Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos