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Rapid spread of Clostridium difficile NAP1/027/ST1 in Chile confirms the emergence of the epidemic strain in Latin America.
Aguayo, C; Flores, R; Lévesque, S; Araya, P; Ulloa, S; Lagos, J; Hormazabal, J C; Tognarelli, J; Ibáñez, D; Pidal, P; Duery, O; Olivares, B; Fernández, J.
Afiliação
  • Aguayo C; Subdepartment of Molecular Genetics,Public Health Institute of Chile,Santiago,Chile.
  • Flores R; National Bacteriology Laboratories,Public Health Institute of Chile,Santiago,Chile.
  • Lévesque S; Laboratoire de santé publique du Québec,Institut national de santé publique du Québec,Québec,Canada.
  • Araya P; National Bacteriology Laboratories,Public Health Institute of Chile,Santiago,Chile.
  • Ulloa S; Subdepartment of Molecular Genetics,Public Health Institute of Chile,Santiago,Chile.
  • Lagos J; Subdepartment of Molecular Genetics,Public Health Institute of Chile,Santiago,Chile.
  • Hormazabal JC; National Bacteriology Laboratories,Public Health Institute of Chile,Santiago,Chile.
  • Tognarelli J; Subdepartment of Molecular Genetics,Public Health Institute of Chile,Santiago,Chile.
  • Ibáñez D; National Bacteriology Laboratories,Public Health Institute of Chile,Santiago,Chile.
  • Pidal P; National Bacteriology Laboratories,Public Health Institute of Chile,Santiago,Chile.
  • Duery O; National Bacteriology Laboratories,Public Health Institute of Chile,Santiago,Chile.
  • Olivares B; Subdepartment of Molecular Genetics,Public Health Institute of Chile,Santiago,Chile.
  • Fernández J; Subdepartment of Molecular Genetics,Public Health Institute of Chile,Santiago,Chile.
Epidemiol Infect ; 143(14): 3069-73, 2015 Oct.
Article em En | MEDLINE | ID: mdl-25687254
Clostridium difficile infection has gained importance in recent years as a result of the rapid spread of epidemic strains, including hypervirulent strains. This study reports the molecular epidemiology of C. difficile obtained from hospitalized patients in Chile. Seven hundred and nineteen isolates of toxigenic C. difficile from 45 hospitals across the country were characterized through toxin profile, pulsed-field gel electrophoresis (PFGE), and sequencing of the tcdC gene. In addition, polymerase chain reaction (PCR) ribotyping and multilocus sequence typing (MLST) were performed on a subset of selected strains. PFGE typing of 719 isolates of C. difficile produced 60 PFGE patterns (subtypes). Subtype 1 was predominant (79% of isolates) and related to the hypervirulent strain (NAP1). Subtype 1 showed 73% relatedness with nine other subtypes, which had a similar tcdC deletion. Subtype 1 corresponded to ribotype 027 and ST1. This report shows the wide dissemination of the hypervirulent strain NAP1/027/ST1 in Chile.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clostridioides difficile / Infecções por Clostridium / Epidemias Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: America do sul / Chile Idioma: En Revista: Epidemiol Infect Assunto da revista: DOENCAS TRANSMISSIVEIS / EPIDEMIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clostridioides difficile / Infecções por Clostridium / Epidemias Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: America do sul / Chile Idioma: En Revista: Epidemiol Infect Assunto da revista: DOENCAS TRANSMISSIVEIS / EPIDEMIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido