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Postinfectious functional gastrointestinal disorders in children: a multicenter prospective study.
Pensabene, Licia; Talarico, Valentina; Concolino, Daniela; Ciliberto, Domenico; Campanozzi, Angelo; Gentile, Teresa; Rutigliano, Vincenzo; Salvatore, Silvia; Staiano, Annamaria; Di Lorenzo, Carlo.
Afiliação
  • Pensabene L; Department of Pediatrics, University Magna Graecia, Catanzaro, Italy. Electronic address: pensabene@unicz.it.
  • Talarico V; Department of Pediatrics, University Magna Graecia, Catanzaro, Italy.
  • Concolino D; Department of Pediatrics, University Magna Graecia, Catanzaro, Italy.
  • Ciliberto D; Department of Oncology, University Magna Graecia, Catanzaro, Italy.
  • Campanozzi A; Department of Pediatrics, University of Foggia, Foggia, Italy.
  • Gentile T; Department of Pediatrics, University of L'Aquila, L'Aquila, Italy.
  • Rutigliano V; Department of Pediatrics, University of Bari, Bari, Italy.
  • Salvatore S; Department of Pediatrics, University of Varese, Varese, Italy.
  • Staiano A; Department of Translational Medical Science, Section of Pediatrics, University of Naples, Naples, Italy.
  • Di Lorenzo C; Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH.
J Pediatr ; 166(4): 903-7.e1, 2015 Apr.
Article em En | MEDLINE | ID: mdl-25661403
OBJECTIVES: To prospectively investigate the occurrence of postinfectious functional gastrointestinal disorders (FGIDs), diagnosed according to the Rome III criteria, in children with acute diarrhea of different infectious etiology. STUDY DESIGN: This was a prospective cohort multicenter study. Children 4-17 years of age presenting with acute diarrhea who tested positive for an enteric infection were recruited within 1 month from the episode and matched with control subjects of similar age and sex. Symptoms were evaluated with a validated questionnaire for FGIDs at the time of enrollment in the study and after 3 and 6 months. RESULTS: A total of 64 patients (36 boys; median age 5.3 years; age range 4.1-14.1 years) were recruited, 32 subjects in each arm. Infections included rotavirus (56.8%), salmonella (30%), adenovirus (6.6%), norovirus (3.3%), and Giardia lamblia (3.3%). FGIDs were significantly more common in exposed patients compared with controls within 1 month from acute diarrhea (40.6% vs 12.5% [P = .02, relative risk (RR) = 1.9]), 3 months (53% vs 15.6% [P = .003, RR = 2.2]), and 6 months (46.8% vs 15.6% [P = .01, RR = 1.9]) later. No correlation was found between different etiologies, age, or sex, and any type of FGIDs. Among exposed children, abdominal pain-related FGIDs were significantly more frequent compared with controls after 6 months from infection (P = .04, RR = 1.7). CONCLUSION: This prospective cohort multicenter study supports postinfectious FGIDs as a true entity in children. There seems to be a significant increase in abdominal pain-related FGIDs after acute diarrhea in children within 1 month and 3 and 6 months later.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gastroenteropatias / Infecções Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gastroenteropatias / Infecções Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos