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Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects.
Torres, Rosângela S L A; Santos, Talita Z; Torres, Robson A A; Pereira, Valéria V G; Fávero, Lucas A F; M Filho, Otavio R; Penkal, Margareth L; Araujo, Leni S.
Afiliação
  • Torres RS; Laboratory of Bacteriology, Epidemiology Laboratory and Disease Control Division, Laboratório Central do Estado do Paraná, Curitiba, PR, Brazil; Universidade Positivo, Curitiba, PR, Brazil. Electronic address: rslatorres@gmail.com.
  • Santos TZ; Pontifícia Universidade Católica do Paraná (PUC-PR), Curitiba, PR, Brazil.
  • Torres RA; Universidade Positivo, Curitiba, PR, Brazil.
  • Pereira VV; Laboratory of Bacteriology, Epidemiology Laboratory and Disease Control Division, Laboratório Central do Estado do Paraná, Curitiba, PR, Brazil.
  • Fávero LA; Universidade Positivo, Curitiba, PR, Brazil.
  • M Filho OR; Universidade Positivo, Curitiba, PR, Brazil.
  • Penkal ML; Laboratory of Bacteriology, Epidemiology Laboratory and Disease Control Division, Laboratório Central do Estado do Paraná, Curitiba, PR, Brazil.
  • Araujo LS; Communicable Disease Surveillance Division, Epidemiology Center, Health Secretariat of the State of Paraná, Curitiba, PR, Brazil.
J Pediatr (Rio J) ; 91(4): 333-8, 2015.
Article em En | MEDLINE | ID: mdl-25623040
OBJECTIVE: Report the incidence, epidemiology, clinical features, death, and vaccination status of patients with whooping cough and perform genotypic characterization of isolates of B. pertussis identified in the state of Paraná, during January 2007 to December 2013. METHODS: Cross-sectional study including 1,209 patients with pertussis. Data were obtained through the Notifiable Diseases Information System (Sistema de Informação de Agravos de Notificação - SINAN) and molecular epidemiology was performed by repetitive sequence-based polymerase chain reaction (rep-PCR; DiversiLab®, bioMerieux, France). RESULTS: The incidence of pertussis in the state of Paraná increased sharply from 0.15-0.76 per 100,000 habitants between 2007-2010 to 1.7-4.28 per 100,000 between 2011-2013. Patients with less than 1 year of age were more stricken (67.5%). Fifty-nine children (5%) developed pertussis even after receiving three doses and two diphtheria-tetanus-pertussis (DTP) boosters vaccine. The most common complications were pneumonia (14.5%), otitis (0.9%), and encephalopathy (0.7%). Isolates of B. pertussis were grouped into two groups (G1 and G2) and eight distinct patterns (G1: P1-P5 and G2: P6-P8). CONCLUSION: The resurgence of pertussis should stimulate new research to develop vaccines with greater capacity of protection against current clones and also encourage implementation of new strategies for vaccination in order to reduce the risk of disease in infants.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bordetella pertussis / Vacina contra Difteria, Tétano e Coqueluche / Coqueluche / Vacinação Tipo de estudo: Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2015 Tipo de documento: Article País de publicação: Brasil
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bordetella pertussis / Vacina contra Difteria, Tétano e Coqueluche / Coqueluche / Vacinação Tipo de estudo: Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2015 Tipo de documento: Article País de publicação: Brasil