Your browser doesn't support javascript.
loading
Vascular alterations underlie developmental problems manifested in cloned cattle before or after birth.
Maiorka, Paulo Cesar; Favaron, Phelipe Oliveira; Mess, Andrea Maria; dos Santos, Caio Rodrigues; Alberto, Miryan Lanca; Meirelles, Flavio Vieira; Miglino, Maria Angelica.
Afiliação
  • Maiorka PC; Department of Pathology, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.
  • Favaron PO; Department of Surgery, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.
  • Mess AM; Department of Surgery, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.
  • dos Santos CR; Department of Pathology, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.
  • Alberto ML; Department of Surgery, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.
  • Meirelles FV; Faculty of Animal Sciences and Food Engineering, University of São Paulo, Pirassununga, Brazil.
  • Miglino MA; Department of Surgery, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.
PLoS One ; 10(1): e0106663, 2015.
Article em En | MEDLINE | ID: mdl-25584533
Although assisted reproductive techniques are commonly applied in humans and animals, they are frequently associated with major developmental deficits and reduced viability. To explore abnormalities associated with cloning or nuclear transfer (NT) as the most invasive of these methods, we used a bovine model to characterize abnormalities. Detailed necropsy examinations were done on 13 calves that died soon after birth; in addition, we included data from embryos and fetuses (produced by NT) that terminated prematurely. Bovine clones that survived until the neonatal period differed quantitatively and qualitatively from in-vivo-derived cattle. Although alterations affected a variety of organs (e.g. heart, lung and liver), there was a clear association with abberant vascular developmental during the early intrauterine phase. Therefore, we concluded that vascular problems were key alterations induced by cloning (presumably via epigenetic modifications).
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clonagem de Organismos / Técnicas de Transferência Nuclear / Malformações Vasculares Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clonagem de Organismos / Técnicas de Transferência Nuclear / Malformações Vasculares Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos