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Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice.
Rachid, Tamiris Lima; Penna-de-Carvalho, Aline; Bringhenti, Isabele; Aguila, Marcia B; Mandarim-de-Lacerda, Carlos A; Souza-Mello, Vanessa.
Afiliação
  • Rachid TL; Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil.
  • Penna-de-Carvalho A; Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil.
  • Bringhenti I; Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil.
  • Aguila MB; Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil.
  • Mandarim-de-Lacerda CA; Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil.
  • Souza-Mello V; Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil. Electronic address: souzamello.uerj@gmail.com.
Mol Cell Endocrinol ; 402: 86-94, 2015 Feb 15.
Article em En | MEDLINE | ID: mdl-25576856
Browning is characterized by the formation of beige/brite fat depots in subcutaneous white adipose tissue (sWAT). This study aimed to examine whether the chronic activation of PPARalpha by fenofibrate could induce beige cell depots in the sWAT of diet-induced obese mice. High-fat fed animals presented overweight, insulin resistance and displayed adverse sWAT remodeling. Fenofibrate significantly attenuated these parameters. Treated groups demonstrated active UCP-1 beige cell clusters within sWAT, confirmed through higher gene expression of PPARalpha, PPARbeta, PGC1alpha, BMP8B, UCP-1, PRDM16 and irisin in treated groups. PPARalpha activation seems to be pivotal to trigger browning through irisin induction and UCP-1 transcription, indicating that fenofibrate increased the expression of genes typical of brown adipose tissue (BAT) in the sWAT, characterizing the formation of beige cells. These findings put forward a possible role of PPARalpha as a promising therapeutic for metabolic diseases via beige cell induction.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenofibrato / Fármacos Antiobesidade / Gordura Subcutânea / Obesidade Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenofibrato / Fármacos Antiobesidade / Gordura Subcutânea / Obesidade Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Mol Cell Endocrinol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda