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Involvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion.
Song, X; Hua, L; Xu, Y; Fang, Z; Wang, Y; Gao, J; Shi, Q; Zhou, X; Yu, R.
Afiliação
  • Song X; Institute of Nervous System Diseases, Xuzhou Medical College, 84 West Huai-hai Road, Xuzhou, 221002, Jiangsu, People's Republic of China.
Clin Transl Oncol ; 17(6): 477-85, 2015 Jun.
Article em En | MEDLINE | ID: mdl-25573158
PURPOSE: The present study aimed at investigating the role and potential mechanism of geranylgeranyltransferase I (GGTase-I) on glioma cell migration and invasion. METHODS: Wound-healing assay and transwell assay were performed to study whether GGTase-I and Ras-like GTPase B (RalB) have effect on glioma cell migration and invasion. RESULTS: We found that knockdown of GGTase-I or RalB both significantly decreased the migratory and invasive abilities of glioma cells. GGTase-I down-regulation suppressed RalB membrane association. Moreover, down-regulation of RalB partially abolished the effect of GGTß over-expression-induced glioma cell migration and invasion increase. CONCLUSIONS: These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alquil e Aril Transferases / Proteínas ral de Ligação ao GTP / Glioma / Invasividade Neoplásica Limite: Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2015 Tipo de documento: Article País de publicação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alquil e Aril Transferases / Proteínas ral de Ligação ao GTP / Glioma / Invasividade Neoplásica Limite: Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2015 Tipo de documento: Article País de publicação: Itália