Involvement of RalB in the effect of geranylgeranyltransferase I on glioma cell migration and invasion.
Clin Transl Oncol
; 17(6): 477-85, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25573158
PURPOSE: The present study aimed at investigating the role and potential mechanism of geranylgeranyltransferase I (GGTase-I) on glioma cell migration and invasion. METHODS: Wound-healing assay and transwell assay were performed to study whether GGTase-I and Ras-like GTPase B (RalB) have effect on glioma cell migration and invasion. RESULTS: We found that knockdown of GGTase-I or RalB both significantly decreased the migratory and invasive abilities of glioma cells. GGTase-I down-regulation suppressed RalB membrane association. Moreover, down-regulation of RalB partially abolished the effect of GGTß over-expression-induced glioma cell migration and invasion increase. CONCLUSIONS: These findings suggest that RalB might be one of the targets for facilitating the invasive phenotype of malignant gliomas induced by GGTase-I.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alquil e Aril Transferases
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Proteínas ral de Ligação ao GTP
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Glioma
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Invasividade Neoplásica
Limite:
Humans
Idioma:
En
Revista:
Clin Transl Oncol
Ano de publicação:
2015
Tipo de documento:
Article
País de publicação:
Itália