Your browser doesn't support javascript.
loading
Stereotactic radiosurgery for pediatric patients with intracranial arteriovenous malformations: variables that may affect obliteration time and probability.
Galván De la Cruz, O O; Ballesteros-Zebadúa, P; Moreno-Jiménez, S; Celis, M A; García-Garduño, O A.
Afiliação
  • Galván De la Cruz OO; Unidad de Radioneurocirugía, Instituto Nacional de Neurología y Neurocirugía, Mexico, Mexico.
  • Ballesteros-Zebadúa P; Laboratorio de Física Médica Instituto Nacional de Neurología y Neurocirugía, Mexico, Mexico. Electronic address: paolabaze@gmail.com.
  • Moreno-Jiménez S; Unidad de Radioneurocirugía, Instituto Nacional de Neurología y Neurocirugía, Mexico, Mexico.
  • Celis MA; Unidad de Radioneurocirugía, Instituto Nacional de Neurología y Neurocirugía, Mexico, Mexico.
  • García-Garduño OA; Laboratorio de Física Médica Instituto Nacional de Neurología y Neurocirugía, Mexico, Mexico.
Clin Neurol Neurosurg ; 129: 62-6, 2015 Feb.
Article em En | MEDLINE | ID: mdl-25549943
INTRODUCTION: It is debatable whether pediatric patients diagnosed with arteriovenous malformations (AVMs) should be treated as adults. Several indexes to classify AVMs have been proposed in the literature, and most try to predict the outcome for each specific treatment. The indexes differ in the variables considered, but they are all based in adult populations. In this study, we analyzed the variables that influence the obliteration time and probability of occurrence in a Mexican pediatric population diagnosed with an AVM and treated with stereotactic radiosurgery (SRS). METHODS: We analyzed 45 pediatric patients (<18 years) with a minimum follow-up of 10 months and a maximum of 112 months. We used logistic regression analysis and Kaplan-Meier curves to evaluate the influence of age, AVM volume, prescribed dose, minimum dose, maximum dose, time of follow-up, sex, previous hemorrhage, venous drainage, treatment technique, previous treatment and location. We also evaluated the predictive power of the following indexes: Spetzler-Martin, RBAS, or K index dose deviation. RESULTS: We found that the radiation technique used may influence the obliteration occurrence (p=0.057). The data suggests that circular arcs are a more efficient treatment technique than dynamic arcs. However, no relationship of dose or volume with treatment technique could be found. Obliteration was also dependent on follow-up time and after three years of follow-up, the obliteration probability decreases (p=0.024). According to Kaplan-Meier analysis, the nidus obliteration time was related with the location according to the Spetzler-Martin index. If the nidus was located in a non-eloquent region, there was a tendency of a shorter obliteration time (p=0.071). CONCLUSION: None of the previously proposed indexes for adults predict obliteration in this pediatric population. Treatment technique, eloquence and follow up time were the only variables that showed influence in obliteration. Since the highest probability of obliteration occurs during the first three years, if the nidus has not been obliterated after this time then another treatment option could be considered.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Malformações Arteriovenosas Intracranianas / Radiocirurgia Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Clin Neurol Neurosurg Ano de publicação: 2015 Tipo de documento: Article País de afiliação: México País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Malformações Arteriovenosas Intracranianas / Radiocirurgia Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Clin Neurol Neurosurg Ano de publicação: 2015 Tipo de documento: Article País de afiliação: México País de publicação: Holanda