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Histological Analysis of γδ T Lymphocytes Infiltrating Human Triple-Negative Breast Carcinomas.
Hidalgo, Jose Villacorta; Bronsert, Peter; Orlowska-Volk, Marzenna; Díaz, Liliana B; Stickeler, Elmar; Werner, Martin; Schmitt-Graeff, Annette; Kayser, Gian; Malkovsky, Miroslav; Fisch, Paul.
Afiliação
  • Hidalgo JV; Department of Pathology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany ; Faculty of Biology, University of Freiburg , Freiburg im Breisgau , Germany ; University Hospital "José de San Martin", University of Buenos Aires , Buenos Aires , Argentina.
  • Bronsert P; Department of Pathology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany ; Comprehensive Cancer Center , Freiburg im Breisgau , Germany.
  • Orlowska-Volk M; Department of Pathology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany.
  • Díaz LB; University Hospital "José de San Martin", University of Buenos Aires , Buenos Aires , Argentina.
  • Stickeler E; Comprehensive Cancer Center , Freiburg im Breisgau , Germany ; Department of Obstetrics and Gynecology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany.
  • Werner M; Department of Pathology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany ; Comprehensive Cancer Center , Freiburg im Breisgau , Germany.
  • Schmitt-Graeff A; Department of Pathology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany.
  • Kayser G; Department of Pathology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany.
  • Malkovsky M; Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health , Madison, WI , USA.
  • Fisch P; Department of Pathology, University of Freiburg Medical Center , Freiburg im Breisgau , Germany.
Front Immunol ; 5: 632, 2014.
Article em En | MEDLINE | ID: mdl-25540645
Breast cancer is the leading cause of cancer death in women and the second most common cancer worldwide after lung cancer. The remarkable heterogeneity of breast cancers influences numerous diagnostic, therapeutic, and prognostic factors. Triple-negative breast carcinomas (TNBCs) lack expression of HER2 and the estrogen and progesterone receptors and often contain lymphocytic infiltrates. Most of TNBCs are invasive ductal carcinomas (IDCs) with poor prognosis, whereas prognostically more favorable subtypes such as medullary breast carcinomas (MBCs) are somewhat less frequent. Infiltrating T-cells have been associated with an improved clinical outcome in TNBCs. The prognostic role of γδ T-cells within CD3(+) tumor-infiltrating T lymphocytes remains unclear. We analyzed 26 TNBCs, 14 IDCs, and 12 MBCs, using immunohistochemistry for the quantity and patterns of γδ T-cell infiltrates within the tumor microenvironment. In both types of TNBCs, we found higher numbers of γδ T-cells in comparison with normal breast tissues and fibroadenomas. The numbers of infiltrating γδ T-cells were higher in MBCs than in IDCs. γδ T-cells in MBCs were frequently located in direct contact with tumor cells, within the tumor and at its invasive border. In contrast, most γδ T-cells in IDCs were found in clusters within the tumor stroma. These findings could be associated with the fact that the patient's prognosis in MBCs is better than that in IDCs. Further studies to characterize these γδ T-cells at the molecular and functional level are in progress.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Immunol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Immunol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Argentina País de publicação: Suíça