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Effects on anemia of drug adjustment in patients with chronic hepatitis C during telaprevir-combined therapy.
Tamori, Akihiro; Kioka, Kiyohide; Sakaguchi, Hiroki; Enomoto, Masaru; Hai, Hoang; Kawamura, Etsushi; Hagihara, Atsushi; Fujii, Hideki; Uchida-Kobayashi, Sawako; Iwai, Shuji; Morikawa, Hiroyasu; Murakami, Yoshiki; Kawasaki, Yasuko; Tsuruta, Daisuke; Kawada, Norifumi.
Afiliação
  • Tamori A; Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Kioka K; Department of Hepatology Osaka City General Hospital, Osaka Japan.
  • Sakaguchi H; Internal Medicine, Izumi Municipal Hospital, Izumi, Japan.
  • Enomoto M; Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Hai H; Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Kawamura E; Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Hagihara A; Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Fujii H; Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Uchida-Kobayashi S; Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Iwai S; Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Morikawa H; Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Murakami Y; Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Kawasaki Y; Department of Hepatology Osaka City General Hospital, Osaka Japan.
  • Tsuruta D; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Kawada N; Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Ann Hepatol ; 14(1): 28-35, 2015.
Article em En | MEDLINE | ID: mdl-25536639
AIM: Anemia is the most common adverse event in patients with chronic hepatitis C virus (HCV) treated with telaprevir (TVR) combined triple therapy. We examined the effects of drug dose adjustment on anemia and a sustained viral response (SVR) during combination therapy. MATERIAL AND METHODS: This study enrolled 62 patients treated with TVR (2,250 mg) for 12 weeks plus pegylated interferon-alpha-2b and ribavirin for 24 weeks. The patients were assigned randomly to the TVR-standard or -reduced groups before treatment. At the occurrence of anemia (hemoglobin < 12 g/dL), the TVR-reduced group received 1500 mg TVR plus the standard dose of ribavirin, whereas the TVR-standard group received the standard TVR dose (2,250 mg) and a reduced dose of ribavirin (200 mg lower than prescribed originally). The safety and SVR at 24 weeks were compared between the TVR-standard (n = 28) and TVR-reduced (n = 25) groups. RESULTS: No differences in the proportion of patients who became HCV RNA-negative were detected between the TVR-standard and -reduced groups (72 and 72% at week 4, 79 and 84% at the end of treatment, and 76 and 80% at SVR24, respectively). Two groups had comparable numbers of adverse events, which led to the discontinuation of TVR in 14 patients of TVR-standard group and in 14 of TVR-reduced group. A lower incidence of renal impairment was observed in the TVR-reduced group (6%) than the TVR-standard group (11%, not statistically significant). CONCLUSIONS: TVR dose adjustment could prevent anemia progression without weakening the anti-viral effect during triple therapy in HCV-patients.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Oligopeptídeos / Polietilenoglicóis / Ribavirina / RNA Viral / Interferon-alfa / Hepatite C Crônica / Anemia Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Japão País de publicação: México
Buscar no Google
Adicionar na Minha BVS
Imprimir
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Oligopeptídeos / Polietilenoglicóis / Ribavirina / RNA Viral / Interferon-alfa / Hepatite C Crônica / Anemia Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Japão País de publicação: México