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Sleep pattern in Charcot-Marie-Tooth disease type 2: report of family case series.
Souza, Cynthia C; Hirotsu, Camila; Neves, Eduardo L A; Santos, Lidiane C L; Costa, Iandra M P F; Garcez, Catarina A; Nunes, Paula S; Antunes, Adriano.
Afiliação
  • Souza CC; Programa de Pós-Graduação em Ciências, Universidade Federal de Sergipe-UFS, Aracaju, SE, Brazil.
  • Hirotsu C; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
  • Neves EL; Programa de Pós-Graduação em Ciências, Universidade Federal de Sergipe-UFS, Aracaju, SE, Brazil.
  • Santos LC; Programa de Pós-Graduação em Ciências, Universidade Federal de Sergipe-UFS, Aracaju, SE, Brazil.
  • Costa IM; Programa de Pós-Graduação em Ciências, Universidade Federal de Sergipe-UFS, Aracaju, SE, Brazil.
  • Garcez CA; Programa de Pós-Graduação em Ciências, Universidade Federal de Sergipe-UFS, Aracaju, SE, Brazil.
  • Nunes PS; Programa de Pós-Graduação em Ciências, Universidade Federal de Sergipe-UFS, Aracaju, SE, Brazil.
  • Antunes A; Programa de Pós-Graduação em Ciências, Universidade Federal de Sergipe-UFS, Aracaju, SE, Brazil.
J Clin Sleep Med ; 11(3): 205-11, 2015 Mar 15.
Article em En | MEDLINE | ID: mdl-25515278
OBJECTIVES: Charcot-Marie-Tooth (CMT) disease is the most prevalent hereditary motor and sensory polyneuropathy, and a condition in which sleep has rarely been studied, particularly in relation to the type 2 (CMT2). Thus, we aimed to characterize the sleep patterns of a family affected by CMT2 disease. METHODS: Sixteen volunteers with CMT2 from the same multigenerational family agreed to participate in the study (refusal rate = 31%). All participants answered sleep questionnaires and came to the sleep laboratory to perform a diagnostic polysomnography (PSG). Clinical manifestation and severity of the disease were also evaluated. RESULTS: 56% of the sample were male and 44% female, with a mean age of 32 ± 17 years, of normal weight (body mass index 21 ± 3 kg/m(2)); 64% presented moderate to severe CMT2. Regarding subjective sleep, 31% had excessive daytime sleepiness and 75% reported poor sleep quality. The PSG results revealed that CMT2 patients had an increase in stage N3 and a reduction in REM sleep, in addition to a high arousal index. Although 81% of the sample were snorers, only 13% had an apnea-hypopnea index (AHI) > 5. However, a positive correlation was found between the severity of disease and the AHI. CONCLUSIONS: Taken together, these data show that CMT2 disease is characterized by important changes in sleep architecture, probably due to sleep fragmentation. Although these alterations may worsen with disease severity, it seems that they are not related to sleep breathing or movement disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Doença de Charcot-Marie-Tooth Tipo de estudo: Etiology_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Clin Sleep Med Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Doença de Charcot-Marie-Tooth Tipo de estudo: Etiology_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J Clin Sleep Med Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos