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Carcinoma ex pleomorphic adenoma of the palate composed of invasive micropapillary salivary duct carcinoma and adenoid cystic carcinoma components: an unusual case with immunohistochemical approach.
Sedassari, Bruno T; da Silva Lascane, Nelise A; Tobouti, Priscila L; Pigatti, Fernanda M; Franco, Maria I F; de Sousa, Suzana C O M.
Afiliação
  • Sedassari BT; From the Oral Pathology Department (BTS, NADSL, PLT, FMP, COMDS); Pathology Department, School of dentistry/University of São Paulo (MIFF), São Paulo, Brazil.
Medicine (Baltimore) ; 93(27): e146, 2014 Dec.
Article em En | MEDLINE | ID: mdl-25501054
Carcinoma ex pleomorphic adenoma (CXPA) is an unusual epithelial malignancy that develops from a primary or recurrent pleomorphic adenoma (PA), the most common tumor of salivary glands, and constitutes about 11.5% of all carcinomas that affect these glands. Intraoral minor salivary glands and seromucous glands of the oropharynx are uncommon locations of CXPA. On histopathological examination, the tumor comprises a wide morphological spectrum with a variable proportion between the benign and malignant components with the latter often predominating and overlapping the PA, which may cause misdiagnosis. Here, we report a case of palatal minor salivary gland CXPA composed of invasive micropapillary salivary duct carcinoma and adenoid cystic carcinoma components with multiple nodal metastases in a 74-year-old woman. Neoplastic cells showed heterogeneous immunohistochemical profile with both luminal and myoepithelial differentiation. The invasive micropapillary salivary duct carcinoma component demonstrated overexpression of the oncoprotein human epidermal growth factor receptor-2. This feature should be considered and evaluated as a possible target for adjuvant therapy in case of metastatic disease.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Carcinoma Papilar / Carcinoma Adenoide Cístico / Adenoma Pleomorfo / Ductos Salivares Limite: Aged / Female / Humans Idioma: En Revista: Medicine (Baltimore) Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Carcinoma Papilar / Carcinoma Adenoide Cístico / Adenoma Pleomorfo / Ductos Salivares Limite: Aged / Female / Humans Idioma: En Revista: Medicine (Baltimore) Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos