Your browser doesn't support javascript.
loading
Reversible dilated cardiomyopathy associated with amphotericin B therapy.
Soares, J R; Nunes, M C P; Leite, A F; Falqueto, E B; Lacerda, B E R A; Ferrari, T C A.
Afiliação
  • Soares JR; Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
J Clin Pharm Ther ; 40(3): 333-5, 2015 Jun.
Article em En | MEDLINE | ID: mdl-25487534
WHAT IS KNOWN AND OBJECTIVE: Amphotericin B (AmB) is commonly used to treat a broad spectrum of fungal infections and leishmaniasis. Its use is limited by numerous adverse effects. Reversible dilated cardiomyopathy associated with AmB is a rare disorder with only four previously reported cases, and all of them referring to patients who presented with a predisposing factor for heart failure. CASE SUMMARY: A previously healthy 45-year-old man with visceral leishmaniasis treated with AmB developed acute dilated cardiomyopathy. Other causes of heart failure as well-known predisposing factors for this condition were ruled out. As with previously reported cases, the cardiac function of our patient returned to normal shortly after. WHAT IS NEW AND CONCLUSION: We describe the first case of dilated cardiomyopathy associated with the administration of AmB in a patient without any known predisposing factor for developing cardiac dysfunction. Available evidence suggests that AmB may induce cardiotoxicity. Further investigations are needed to clarify this issue.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Dilatada / Anfotericina B / Leishmaniose Visceral / Antiprotozoários Tipo de estudo: Risk_factors_studies Limite: Humans / Male / Middle aged Idioma: En Revista: J Clin Pharm Ther Assunto da revista: FARMACIA / TERAPEUTICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Dilatada / Anfotericina B / Leishmaniose Visceral / Antiprotozoários Tipo de estudo: Risk_factors_studies Limite: Humans / Male / Middle aged Idioma: En Revista: J Clin Pharm Ther Assunto da revista: FARMACIA / TERAPEUTICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido