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The role of lipotoxicity in smoke cardiomyopathy.
Santos, Priscila P; Oliveira, Fernando; Ferreira, Vanessa C M P; Polegato, Bertha F; Roscani, Meliza G; Fernandes, Ana Angelica; Modesto, Pamela; Rafacho, Bruna P M; Zanati, Silmeia G; Di Lorenzo, Annarita; Matsubara, Luiz S; Paiva, Sergio A R; Zornoff, Leonardo A M; Minicucci, Marcos F; Azevedo, Paula S.
Afiliação
  • Santos PP; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Oliveira F; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Ferreira VC; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Polegato BF; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Roscani MG; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Fernandes AA; Chemistry and Biochemistry Department, Instituto de Biociências de Botucatu, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Modesto P; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Rafacho BP; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Zanati SG; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Di Lorenzo A; Department of Pathology and Laboratory Medicine, Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York, United States of America.
  • Matsubara LS; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Paiva SA; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Zornoff LA; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Minicucci MF; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
  • Azevedo PS; Internal Medicine Department, Botucatu Medical School, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
PLoS One ; 9(12): e113739, 2014.
Article em En | MEDLINE | ID: mdl-25462161
BACKGROUND/AIMS: Experimental and clinical studies have shown the direct toxic effects of cigarette smoke (CS) on the myocardium, independent of vascular effects. However, the underlying mechanisms are not well known. METHODS: Wistar rats were allocated to control (C) and cigarette smoke (CS) groups. CS rats were exposed to cigarette smoke for 2 months. RESULTS: After that morphometric, functional and biochemical parameters were measured. The echocardiographic study showed enlargement of the left atria, increase in the left ventricular systolic volume and reduced systolic function. Within the cardiac metabolism, exposure to CS decreased beta hydroxy acyl coenzyme A dehydrogenases and citrate synthases and increased lactate dehydrogenases. Peroxisome proliferator-activated receptor alpha (PPARα) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) were expressed similarly in both groups. CS increased serum lipids and myocardial triacylglycerols (TGs). These data suggest that impairment in fatty acid oxidation and the accumulation of cardiac lipids characterize lipotoxicity. CS group exhibited increased oxidative stress and decreased antioxidant defense. Finally, the myocyte cross-sectional area and active Caspase 3 were increased in the CS group. CONCLUSION: The cardiac remodeling that was observed in the CS exposure model may be explained by abnormalities in energy metabolism, including lipotoxicity and oxidative stress.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fumar / Estresse Oxidativo / Cardiomiopatias / Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fumar / Estresse Oxidativo / Cardiomiopatias / Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos