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Topical curcumin-loaded hydrogels obtained using galactomannan from Schizolobium parahybae and xanthan.
Koop, Heidegrid Siebert; de Freitas, Rilton Alves; de Souza, Márcia Maria; Savi, Roberto; Silveira, Joana Léa Meira.
Afiliação
  • Koop HS; Department of Biochemistry and Molecular Biology, Federal University of Paraná, P.B. 19046, Centro Politécnico, CEP 81531-990 Curitiba, PR, Brazil.
  • de Freitas RA; Department of Chemistry, Federal University of Paraná, P.B. 19046, Centro Politécnico, CEP 81531-990 Curitiba, PR, Brazil.
  • de Souza MM; Postgraduate Program at Pharmaceutical Sciences, University of Vale do Itajaí, Itajaí, Brazil.
  • Savi R; Department of Biochemistry and Molecular Biology, Federal University of Paraná, P.B. 19046, Centro Politécnico, CEP 81531-990 Curitiba, PR, Brazil.
  • Silveira JL; Department of Biochemistry and Molecular Biology, Federal University of Paraná, P.B. 19046, Centro Politécnico, CEP 81531-990 Curitiba, PR, Brazil. Electronic address: jlms12@yahoo.com.
Carbohydr Polym ; 116: 229-36, 2015 02 13.
Article em En | MEDLINE | ID: mdl-25458294
The curcumin (CUR)-loaded binary hydrogel was formulated using xanthan and galactomannan from Schizolobium parahybae (guapuruvu). The binary hydrogels presented gel characteristics, stable pH values and mechanical stress resistance even after 45 days of heat exposure (45 °C). The CUR-loaded hydrogel content was 98.6% for XGMC (xanthan and galactomannan with CUR-microemulsion) after the stability test. The in vitro cytotoxicity analysis suggested non-cutaneous membrane irritation, and the in vitro skin permeation analysis indicated 2.15 to 2.50 µg mL(-1) CUR at the stratum corneum, epidermal and dermal levels. The XGEC (xanthan and galactomannan with CUR solubilized in ethanol) and XGMC hydrogels presented 76.8 and 63.2% inhibition of topical inflammation, respectively. Chemical stability and non-cytotoxicity analysis confirm the safety of prolonged exposure of the skin during the topical treatment, offering long-lasting XGEC and XGMC action.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos Bacterianos / Hidrogéis / Curcumina / Fabaceae / Mananas / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Carbohydr Polym Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos Bacterianos / Hidrogéis / Curcumina / Fabaceae / Mananas / Anti-Inflamatórios Limite: Animals Idioma: En Revista: Carbohydr Polym Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido