Cyanide intoxication--I. An oral chronic animal model.

Buzaleh, A M; Vazquez, E S; Batlle, A M

Buzaleh, A M; Vazquez, E S; Batlle, A M.

Afiliação

Buzaleh AM; Centro de Investigaciones sobre Porfirinas y Porfirias, CONICET, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Argentina.

Gen Pharmacol ; 20(3): 323-7, 1989.

Article em En | MEDLINE | ID: mdl-2545508

RESUMO

The effects of oral chronic cyanide administration to mice were studied. Cyanide intoxication was confirmed by the increased levels of this poison and the concomitant inhibition of cytochrome oxidase activity in liver, brain, heart and blood. The detoxifying enzyme rhodanese was measured. The state of the sulfane sulfur pool was investigated by determination of the cyanide labile-sulfur levels. A clear correlation between rhodanese activity and sulfur content was obtained as a consequence of cyanide action. These results support the belief that rhodanese plays a fundamental role in the detoxification process of cyanide, in preventing cyanide reaching the target tissues.

Assuntos

Cianetos/intoxicação; Administração Oral; Animais; Cianetos/metabolismo; Complexo IV da Cadeia de Transporte de Elétrons/metabolismo; Camundongos; Proteínas/metabolismo; Enxofre/metabolismo; Tiocianatos/metabolismo; Tiossulfato Sulfurtransferase/metabolismo; Fatores de Tempo

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cianetos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Gen Pharmacol Ano de publicação: 1989 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido

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